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- W2005019768 abstract "Periodontal ligament fibroblasts contracting collagen gels changed their phenotype in accordance with the stages of gel compaction. In the early and active phase of gel compaction, the fibroblasts exhibited numerous cell processes containing microfilamentous material and few organelles, little RER and Golgi membranes, but many free ribosomes, numerous structures resembling gap junctions, and a rich cell coat. Fibroblasts changed to a more rounded, relaxed state after 24 hr when the gel was compacted. At this stage, extensive RER and Golgi membranes, small peripheral microfilament bundles, little cell coat, and few, if any, gap junctions were observed. On the other hand fibroblasts plated on plastic exhibited prominent RER and Golgi membranes, peripheral microfilament bundles, and junctions of the adhaerens type. The results suggest that so-called “myofibroblasts”, which have been described as being prominent in the granulation tissue of contracting wounds, represent a reversible phenotypic modulation of fibroblast-type cells to a contractile state." @default.
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- W2005019768 date "1982-02-01" @default.
- W2005019768 modified "2023-09-26" @default.
- W2005019768 title "Fibroblasts contracting three-dimensional collagen gels exhibit ultrastructure consistent with either contraction or protein secretion" @default.
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- W2005019768 doi "https://doi.org/10.1016/s0022-5320(82)80022-1" @default.
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