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- W2005021048 abstract "Oral insulin is one of the most exciting areas of development in the treatment of diabetes because of its potential benefit in patient convenience, rapid insulinization of liver, adequate insulin delivery avoiding peripheral hyperinsulinaemia while potentially avoiding adverse effects of weight gain and hypoglycaemia. Growing evidence that earlier initiation of intensive insulin therapy produces sustained tight glycaemic control resulting in substantial delay in complications makes an effective oral insulin product even more vital for the management of patients with diabetes. Despite knowledge of this unmet medical need, oral delivery of insulin has been unsuccessful because of several barriers. For several decades, researchers have tried to develop oral insulin using various technologies without much clinical or commercial success. This review summarizes the development status of oral insulins which are publicly reported to be undergoing clinical studies. Currently, two oral insulin products are in an advanced stage of clinical development and first data from long-term therapy are expected to be available in the second half of 2010." @default.
- W2005021048 created "2016-06-24" @default.
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- W2005021048 date "2010-03-01" @default.
- W2005021048 modified "2023-10-02" @default.
- W2005021048 title "Oral insulin - a review of current status" @default.
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- W2005021048 doi "https://doi.org/10.1111/j.1463-1326.2009.01150.x" @default.
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