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- W2005021857 abstract "Iodolactones 5 and 11 have been prepared in asymmetric form from a common precursor carboxylic acid 4. These iodolactones were then transformed into lactones 7 and 12, respectively. Lactones 7 and 12 were converted to potent HIV-1 protease inhibitors 1 and 2, respectively, by a five-step sequence. Lactones 7 and 12 were also prepared in a 1:1 ratio from epoxide 14." @default.
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- W2005021857 date "1994-01-01" @default.
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- W2005021857 title "Asymmetric synthesis of cis- and trans-γ-lactones useful in HIV-1 protease inhibitor synthesis" @default.
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- W2005021857 doi "https://doi.org/10.1016/s0960-894x(01)80260-2" @default.
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