Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005023775> ?p ?o ?g. }
- W2005023775 endingPage "1907" @default.
- W2005023775 startingPage "1899" @default.
- W2005023775 abstract "We aimed to determine prospectively whether rivastigmine, an inhibitor of acetylcholinesterase and butyrylcholinesterase, provided benefits in patients with and without visual hallucinations in a population with dementia associated with Parkinson's disease (PDD). This was a 24-week double-blind placebo-controlled study. Primary efficacy measures were the Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) and Alzheimer's Disease Cooperative Study-Clinician's Global Impression of Change (ADCS-CGIC). Secondary efficacy measures included activities of daily living, behavioral symptoms, and executive and attentional functions. Patients were stratified according to the presence of visual hallucinations at baseline. The study included 188 visual hallucinators (118 on rivastigmine, 70 on placebo) and 348 nonvisual hallucinators (239 on rivastigmine, 109 on placebo). Rivastigmine provided benefits in both visual hallucinators and nonvisual hallucinators. Absolute responses to rivastigmine on the ADAS-cog were comparable over 6 months, although rivastigmine-placebo differences tended to be larger in visual hallucinators (4.27; P = 0.002) than in nonhallucinators (2.09; P = 0.015). On the ADCS-CGIC, differences between rivastigmine and placebo were 0.5 in visual hallucinators (P = 0.030) and 0.3 in nonhallucinators (P = 0.111). Rivastigmine provided benefits on all secondary efficacy measures, and placebo declines and treatment differences were more marked in visual hallucinators. Adverse events were reported more frequently by rivastigmine-treated patients, although this difference was less marked in visual hallucinators. Visual hallucinations appear to predict more rapid decline and possibly greater therapeutic benefit from rivastigmine treatment in PDD." @default.
- W2005023775 created "2016-06-24" @default.
- W2005023775 creator A5003002074 @default.
- W2005023775 creator A5010057774 @default.
- W2005023775 creator A5025627745 @default.
- W2005023775 creator A5027033208 @default.
- W2005023775 creator A5051934606 @default.
- W2005023775 creator A5062259358 @default.
- W2005023775 creator A5069815031 @default.
- W2005023775 date "2006-09-07" @default.
- W2005023775 modified "2023-10-16" @default.
- W2005023775 title "Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease" @default.
- W2005023775 cites W1164896577 @default.
- W2005023775 cites W1847168837 @default.
- W2005023775 cites W1953027527 @default.
- W2005023775 cites W1984475571 @default.
- W2005023775 cites W1990627055 @default.
- W2005023775 cites W1996776294 @default.
- W2005023775 cites W1999991503 @default.
- W2005023775 cites W2041646635 @default.
- W2005023775 cites W2053550022 @default.
- W2005023775 cites W2075478727 @default.
- W2005023775 cites W2075960947 @default.
- W2005023775 cites W2083220625 @default.
- W2005023775 cites W2083495334 @default.
- W2005023775 cites W2090101179 @default.
- W2005023775 cites W2111963393 @default.
- W2005023775 cites W2115026925 @default.
- W2005023775 cites W2115455636 @default.
- W2005023775 cites W2132881915 @default.
- W2005023775 cites W2135031277 @default.
- W2005023775 cites W2155610689 @default.
- W2005023775 cites W2163561899 @default.
- W2005023775 cites W2276024626 @default.
- W2005023775 cites W2589302021 @default.
- W2005023775 doi "https://doi.org/10.1002/mds.21077" @default.
- W2005023775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16960863" @default.
- W2005023775 hasPublicationYear "2006" @default.
- W2005023775 type Work @default.
- W2005023775 sameAs 2005023775 @default.
- W2005023775 citedByCount "266" @default.
- W2005023775 countsByYear W20050237752012 @default.
- W2005023775 countsByYear W20050237752013 @default.
- W2005023775 countsByYear W20050237752014 @default.
- W2005023775 countsByYear W20050237752015 @default.
- W2005023775 countsByYear W20050237752016 @default.
- W2005023775 countsByYear W20050237752017 @default.
- W2005023775 countsByYear W20050237752018 @default.
- W2005023775 countsByYear W20050237752019 @default.
- W2005023775 countsByYear W20050237752020 @default.
- W2005023775 countsByYear W20050237752021 @default.
- W2005023775 countsByYear W20050237752022 @default.
- W2005023775 countsByYear W20050237752023 @default.
- W2005023775 crossrefType "journal-article" @default.
- W2005023775 hasAuthorship W2005023775A5003002074 @default.
- W2005023775 hasAuthorship W2005023775A5010057774 @default.
- W2005023775 hasAuthorship W2005023775A5025627745 @default.
- W2005023775 hasAuthorship W2005023775A5027033208 @default.
- W2005023775 hasAuthorship W2005023775A5051934606 @default.
- W2005023775 hasAuthorship W2005023775A5062259358 @default.
- W2005023775 hasAuthorship W2005023775A5069815031 @default.
- W2005023775 hasConcept C118552586 @default.
- W2005023775 hasConcept C126322002 @default.
- W2005023775 hasConcept C142724271 @default.
- W2005023775 hasConcept C15744967 @default.
- W2005023775 hasConcept C204787440 @default.
- W2005023775 hasConcept C27081682 @default.
- W2005023775 hasConcept C2776000289 @default.
- W2005023775 hasConcept C2776332859 @default.
- W2005023775 hasConcept C2779134260 @default.
- W2005023775 hasConcept C2779483572 @default.
- W2005023775 hasConcept C2779734285 @default.
- W2005023775 hasConcept C2780904820 @default.
- W2005023775 hasConcept C2908998935 @default.
- W2005023775 hasConcept C548259974 @default.
- W2005023775 hasConcept C71924100 @default.
- W2005023775 hasConceptScore W2005023775C118552586 @default.
- W2005023775 hasConceptScore W2005023775C126322002 @default.
- W2005023775 hasConceptScore W2005023775C142724271 @default.
- W2005023775 hasConceptScore W2005023775C15744967 @default.
- W2005023775 hasConceptScore W2005023775C204787440 @default.
- W2005023775 hasConceptScore W2005023775C27081682 @default.
- W2005023775 hasConceptScore W2005023775C2776000289 @default.
- W2005023775 hasConceptScore W2005023775C2776332859 @default.
- W2005023775 hasConceptScore W2005023775C2779134260 @default.
- W2005023775 hasConceptScore W2005023775C2779483572 @default.
- W2005023775 hasConceptScore W2005023775C2779734285 @default.
- W2005023775 hasConceptScore W2005023775C2780904820 @default.
- W2005023775 hasConceptScore W2005023775C2908998935 @default.
- W2005023775 hasConceptScore W2005023775C548259974 @default.
- W2005023775 hasConceptScore W2005023775C71924100 @default.
- W2005023775 hasIssue "11" @default.
- W2005023775 hasLocation W20050237751 @default.
- W2005023775 hasLocation W20050237752 @default.
- W2005023775 hasOpenAccess W2005023775 @default.
- W2005023775 hasPrimaryLocation W20050237751 @default.
- W2005023775 hasRelatedWork W1966410162 @default.
- W2005023775 hasRelatedWork W1984064245 @default.