FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005027470> ?p ?o ?g. }

• W2005027470 endingPage "477" @default.
• W2005027470 startingPage "467" @default.
• W2005027470 abstract "A neuroprotected state can be acquired by preconditioning brain with a stimulus that is subthreshold for damage (tolerance). Acquisition of tolerance involves coordinate, bi-directional changes to gene expression levels and the re-programmed phenotype is determined by the preconditioning stimulus. While best studied in ischemic brain there is evidence brief seizures can confer tolerance against prolonged seizures (status epilepticus). Presently, we developed a model of epileptic preconditioning in mice and used microarrays to gain insight into the transcriptional phenotype within the target hippocampus at the time tolerance had been acquired. Epileptic tolerance was induced by an episode of non-damaging seizures in adult C57Bl/6 mice using a systemic injection of kainic acid. Neuron and DNA damage-positive cell counts 24 h after status epilepticus induced by intraamygdala microinjection of kainic acid revealed preconditioning given 24 h prior reduced CA3 neuronal death by ∼45% compared with non-tolerant seizure mice. Microarray analysis of over 39,000 transcripts (Affymetrix 430 2.0 chip) from microdissected CA3 subfields was undertaken at the point at which tolerance was acquired. Results revealed a unique profile of small numbers of equivalently up- and down-regulated genes with biological functions that included transport and localization, ubiquitin metabolism, apoptosis and cell cycle control. Select microarray findings were validated post hoc by real-time polymerase chain reaction and Western blotting. The present study defines a paradigm for inducing epileptic preconditioning in mice and first insight into the global transcriptome of the seizure-damage refractory brain." @default.
• W2005027470 created "2016-06-24" @default.
• W2005027470 creator A5002978004 @default.
• W2005027470 creator A5011179401 @default.
• W2005027470 creator A5043113948 @default.
• W2005027470 creator A5049041331 @default.
• W2005027470 creator A5053358105 @default.
• W2005027470 creator A5067688200 @default.
• W2005027470 creator A5069808116 @default.
• W2005027470 creator A5070403963 @default.
• W2005027470 creator A5075015717 @default.
• W2005027470 creator A5087179037 @default.
• W2005027470 creator A5088004358 @default.
• W2005027470 date "2007-12-01" @default.
• W2005027470 modified "2023-10-16" @default.
• W2005027470 title "Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning" @default.
• W2005027470 cites W1494002665 @default.
• W2005027470 cites W1505115830 @default.
• W2005027470 cites W1508232918 @default.
• W2005027470 cites W1526269078 @default.
• W2005027470 cites W1533140355 @default.
• W2005027470 cites W1553653089 @default.
• W2005027470 cites W1647455825 @default.
• W2005027470 cites W1983420534 @default.
• W2005027470 cites W1983458353 @default.
• W2005027470 cites W1986306041 @default.
• W2005027470 cites W1989483418 @default.
• W2005027470 cites W1989779461 @default.
• W2005027470 cites W1990849310 @default.
• W2005027470 cites W1993841014 @default.
• W2005027470 cites W1998492363 @default.
• W2005027470 cites W2000873756 @default.
• W2005027470 cites W2003723352 @default.
• W2005027470 cites W2004880366 @default.
• W2005027470 cites W2006739799 @default.
• W2005027470 cites W2009812062 @default.
• W2005027470 cites W2016079510 @default.
• W2005027470 cites W2020450325 @default.
• W2005027470 cites W2024289624 @default.
• W2005027470 cites W2038707186 @default.
• W2005027470 cites W2038920951 @default.
• W2005027470 cites W2043033529 @default.
• W2005027470 cites W2043595793 @default.
• W2005027470 cites W2045292808 @default.
• W2005027470 cites W2050710535 @default.
• W2005027470 cites W2053174644 @default.
• W2005027470 cites W2060699509 @default.
• W2005027470 cites W2062648533 @default.
• W2005027470 cites W2063175209 @default.
• W2005027470 cites W2070932938 @default.
• W2005027470 cites W2080027027 @default.
• W2005027470 cites W2081440091 @default.
• W2005027470 cites W2083644948 @default.
• W2005027470 cites W2091827844 @default.
• W2005027470 cites W2103839002 @default.
• W2005027470 cites W2109220101 @default.
• W2005027470 cites W2115314977 @default.
• W2005027470 cites W2117581921 @default.
• W2005027470 cites W2118648879 @default.
• W2005027470 cites W2123147219 @default.
• W2005027470 cites W2129839751 @default.
• W2005027470 cites W2130778603 @default.
• W2005027470 cites W2143807539 @default.
• W2005027470 cites W2154696007 @default.
• W2005027470 cites W2156935469 @default.
• W2005027470 cites W2160076767 @default.
• W2005027470 cites W2160254795 @default.
• W2005027470 cites W2161456882 @default.
• W2005027470 cites W2166751395 @default.
• W2005027470 cites W4237405922 @default.
• W2005027470 doi "https://doi.org/10.1016/j.neuroscience.2007.09.020" @default.
• W2005027470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268097" @default.
• W2005027470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17935890" @default.
• W2005027470 hasPublicationYear "2007" @default.
• W2005027470 type Work @default.
• W2005027470 sameAs 2005027470 @default.
• W2005027470 citedByCount "47" @default.
• W2005027470 countsByYear W20050274702012 @default.
• W2005027470 countsByYear W20050274702013 @default.
• W2005027470 countsByYear W20050274702014 @default.
• W2005027470 countsByYear W20050274702015 @default.
• W2005027470 countsByYear W20050274702016 @default.
• W2005027470 countsByYear W20050274702017 @default.
• W2005027470 countsByYear W20050274702018 @default.
• W2005027470 countsByYear W20050274702019 @default.
• W2005027470 countsByYear W20050274702021 @default.
• W2005027470 crossrefType "journal-article" @default.
• W2005027470 hasAuthorship W2005027470A5002978004 @default.
• W2005027470 hasAuthorship W2005027470A5011179401 @default.
• W2005027470 hasAuthorship W2005027470A5043113948 @default.
• W2005027470 hasAuthorship W2005027470A5049041331 @default.
• W2005027470 hasAuthorship W2005027470A5053358105 @default.
• W2005027470 hasAuthorship W2005027470A5067688200 @default.
• W2005027470 hasAuthorship W2005027470A5069808116 @default.
• W2005027470 hasAuthorship W2005027470A5070403963 @default.
• W2005027470 hasAuthorship W2005027470A5075015717 @default.
• W2005027470 hasAuthorship W2005027470A5087179037 @default.
• W2005027470 hasAuthorship W2005027470A5088004358 @default.

• next