Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005028972> ?p ?o ?g. }
- W2005028972 endingPage "3368" @default.
- W2005028972 startingPage "3358" @default.
- W2005028972 abstract "Abstract During amphibian metamorphosis, most or all of the larval intestinal epithelial cells undergo apoptosis. In contrast, stem cells of yet‐unknown origin actively proliferate and, under the influence of the connective tissue, differentiate into the adult epithelium analogous to the mammalian counterpart. Thus, amphibian intestinal remodeling is useful for studying the stem cell niche, the clarification of which is urgently needed for regenerative therapies. This review highlights the molecular aspects of the niche using the Xenopus laevis intestine as a model. Because amphibian metamorphosis is completely controlled by thyroid hormone (TH), the analysis of TH response genes serves as a powerful means for clarifying its molecular mechanisms. Although functional analysis of the genes is still on the way, recent progresses in organ culture and transgenic studies have gradually uncovered important roles of cell–cell and cell–extracellular matrix interactions through stromelysin‐3 and sonic hedgehog/bone morphogenetic protein‐4 signaling pathway in the epithelial stem cell development. Developmental Dynamics 236:3358–3368, 2007. © 2007 Wiley‐Liss, Inc." @default.
- W2005028972 created "2016-06-24" @default.
- W2005028972 creator A5031341871 @default.
- W2005028972 creator A5038200182 @default.
- W2005028972 date "2007-08-17" @default.
- W2005028972 modified "2023-09-27" @default.
- W2005028972 title "Regulation of adult intestinal epithelial stem cell development by thyroid hormone duringXenopus laevis metamorphosis" @default.
- W2005028972 cites W1180108146 @default.
- W2005028972 cites W1481500905 @default.
- W2005028972 cites W1517748724 @default.
- W2005028972 cites W1530364143 @default.
- W2005028972 cites W1579295790 @default.
- W2005028972 cites W1607596367 @default.
- W2005028972 cites W1663165115 @default.
- W2005028972 cites W1849320548 @default.
- W2005028972 cites W1894541755 @default.
- W2005028972 cites W1927398280 @default.
- W2005028972 cites W1958670379 @default.
- W2005028972 cites W1967159322 @default.
- W2005028972 cites W1972571085 @default.
- W2005028972 cites W1974133941 @default.
- W2005028972 cites W1974272163 @default.
- W2005028972 cites W1975664461 @default.
- W2005028972 cites W1975774582 @default.
- W2005028972 cites W1976678735 @default.
- W2005028972 cites W1977305659 @default.
- W2005028972 cites W1978805275 @default.
- W2005028972 cites W1979258110 @default.
- W2005028972 cites W1979345102 @default.
- W2005028972 cites W1983344050 @default.
- W2005028972 cites W1984059331 @default.
- W2005028972 cites W1987513354 @default.
- W2005028972 cites W1989024959 @default.
- W2005028972 cites W1993110996 @default.
- W2005028972 cites W1994288110 @default.
- W2005028972 cites W1994734055 @default.
- W2005028972 cites W1995060691 @default.
- W2005028972 cites W2003500892 @default.
- W2005028972 cites W2004661553 @default.
- W2005028972 cites W2005113993 @default.
- W2005028972 cites W2011205303 @default.
- W2005028972 cites W2011268627 @default.
- W2005028972 cites W2011663421 @default.
- W2005028972 cites W2012917028 @default.
- W2005028972 cites W2015272152 @default.
- W2005028972 cites W2015359970 @default.
- W2005028972 cites W2017468610 @default.
- W2005028972 cites W2022779216 @default.
- W2005028972 cites W2023002162 @default.
- W2005028972 cites W2023649138 @default.
- W2005028972 cites W2024810164 @default.
- W2005028972 cites W2025019677 @default.
- W2005028972 cites W2026356975 @default.
- W2005028972 cites W2031917908 @default.
- W2005028972 cites W2034327940 @default.
- W2005028972 cites W2035538797 @default.
- W2005028972 cites W2036795046 @default.
- W2005028972 cites W2037910991 @default.
- W2005028972 cites W2040748502 @default.
- W2005028972 cites W2043254359 @default.
- W2005028972 cites W2044351980 @default.
- W2005028972 cites W2050983516 @default.
- W2005028972 cites W2052267280 @default.
- W2005028972 cites W2052986155 @default.
- W2005028972 cites W2053282464 @default.
- W2005028972 cites W2054632229 @default.
- W2005028972 cites W2054925414 @default.
- W2005028972 cites W2056199674 @default.
- W2005028972 cites W2059642813 @default.
- W2005028972 cites W2063770260 @default.
- W2005028972 cites W2065498718 @default.
- W2005028972 cites W2067300770 @default.
- W2005028972 cites W2067526109 @default.
- W2005028972 cites W2069143148 @default.
- W2005028972 cites W2072577774 @default.
- W2005028972 cites W2074597244 @default.
- W2005028972 cites W2076090563 @default.
- W2005028972 cites W2081471404 @default.
- W2005028972 cites W2082563193 @default.
- W2005028972 cites W2084069977 @default.
- W2005028972 cites W2086152184 @default.
- W2005028972 cites W2087244276 @default.
- W2005028972 cites W2089123082 @default.
- W2005028972 cites W2092642151 @default.
- W2005028972 cites W2093520446 @default.
- W2005028972 cites W2095498651 @default.
- W2005028972 cites W2098278242 @default.
- W2005028972 cites W2101992049 @default.
- W2005028972 cites W2102270036 @default.
- W2005028972 cites W2104593931 @default.
- W2005028972 cites W2107534382 @default.
- W2005028972 cites W2109625553 @default.
- W2005028972 cites W2109658199 @default.
- W2005028972 cites W2112562113 @default.
- W2005028972 cites W2112657094 @default.
- W2005028972 cites W2118016890 @default.
- W2005028972 cites W2122190521 @default.
- W2005028972 cites W2122785077 @default.