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- W2005031444 abstract "The etiology of Graves’ orbitopathy (GO) remains enigmatic and thus controversy surrounds its pathogenesis. The role of the thyroid stimulating hormone receptor (TSHR) and activating antibodies directed against it in the hyperthyroidism of Graves’ disease (GD) is firmly established. Less well elucidated is what part the TSHR pathway might play in the development of GO. Also uncertain is the participation of other cell surface receptors in the disease. Elevated levels of insulin-like growth factor-1 receptor (IGF-1R) have been found in orbital fibroblasts as well as B and T cells from patients with GD. These abnormal patterns of IGF-1R display are also found in rheumatoid arthritis and carry functional consequences. In addition, activating IgGs capable of displacing IGF-1 from IGF-1R have also been detected in patients with these diseases. IGF-1R forms a complex with TSHR which is necessary for at least some of the non-canonical signaling observed following TSHR activation. Functional TSHR and IGF-1R have also been found on fibrocytes, CD34+ bone marrow-derived cells from the monocyte lineage. Levels of TSHR on fibrocytes greatly exceed those found on orbital fibroblasts. When ligated by TSH or M22, a TSHR-activating monoclonal antibody, fibrocytes produce extremely high levels of several cytokines and chemokines. Moreover, fibrocytes infiltrate both the orbit and thyroid in GD. In sum, based on current evidence, IGF-1R and TSHR can be thought of as “partners in crime”. Involvement of the former probably transcends disease boundaries, while TSHR may not." @default.
- W2005031444 created "2016-06-24" @default.
- W2005031444 creator A5038476807 @default.
- W2005031444 creator A5039528393 @default.
- W2005031444 creator A5077112559 @default.
- W2005031444 date "2012-06-01" @default.
- W2005031444 modified "2023-10-18" @default.
- W2005031444 title "Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves’ orbitopathy" @default.
- W2005031444 cites W1485275533 @default.
- W2005031444 cites W1491773178 @default.
- W2005031444 cites W1577717705 @default.
- W2005031444 cites W1635774835 @default.
- W2005031444 cites W1856370030 @default.
- W2005031444 cites W1858708606 @default.
- W2005031444 cites W1930521840 @default.
- W2005031444 cites W1973225811 @default.
- W2005031444 cites W1974535035 @default.
- W2005031444 cites W1975204912 @default.
- W2005031444 cites W1978416746 @default.
- W2005031444 cites W1979248814 @default.
- W2005031444 cites W1983311932 @default.
- W2005031444 cites W1985721869 @default.
- W2005031444 cites W1992997083 @default.
- W2005031444 cites W1995960088 @default.
- W2005031444 cites W1998149673 @default.
- W2005031444 cites W2000935451 @default.
- W2005031444 cites W2002052645 @default.
- W2005031444 cites W2003199291 @default.
- W2005031444 cites W2004749193 @default.
- W2005031444 cites W2011324493 @default.
- W2005031444 cites W2019772553 @default.
- W2005031444 cites W2021086063 @default.
- W2005031444 cites W2024029731 @default.
- W2005031444 cites W2025602909 @default.
- W2005031444 cites W2030419597 @default.
- W2005031444 cites W2030974372 @default.
- W2005031444 cites W2032362320 @default.
- W2005031444 cites W2033970109 @default.
- W2005031444 cites W2037999444 @default.
- W2005031444 cites W2041439225 @default.
- W2005031444 cites W2044157028 @default.
- W2005031444 cites W2046809898 @default.
- W2005031444 cites W2051557590 @default.
- W2005031444 cites W2051672357 @default.
- W2005031444 cites W2059055637 @default.
- W2005031444 cites W2060458730 @default.
- W2005031444 cites W2061039366 @default.
- W2005031444 cites W2062268542 @default.
- W2005031444 cites W2063294738 @default.
- W2005031444 cites W2063823126 @default.
- W2005031444 cites W2065139547 @default.
- W2005031444 cites W2069519523 @default.
- W2005031444 cites W2070436387 @default.
- W2005031444 cites W2071244314 @default.
- W2005031444 cites W2072032096 @default.
- W2005031444 cites W2075653298 @default.
- W2005031444 cites W2077343072 @default.
- W2005031444 cites W2082457469 @default.
- W2005031444 cites W2082857875 @default.
- W2005031444 cites W2084872482 @default.
- W2005031444 cites W2086457902 @default.
- W2005031444 cites W2092817365 @default.
- W2005031444 cites W2097810402 @default.
- W2005031444 cites W2100082817 @default.
- W2005031444 cites W2100345921 @default.
- W2005031444 cites W2101657267 @default.
- W2005031444 cites W2101850049 @default.
- W2005031444 cites W2109007966 @default.
- W2005031444 cites W2109568147 @default.
- W2005031444 cites W2111136901 @default.
- W2005031444 cites W2111267090 @default.
- W2005031444 cites W2112406344 @default.
- W2005031444 cites W2112748791 @default.
- W2005031444 cites W2114304073 @default.
- W2005031444 cites W2117451443 @default.
- W2005031444 cites W2117537530 @default.
- W2005031444 cites W2121538275 @default.
- W2005031444 cites W2125584590 @default.
- W2005031444 cites W2125892243 @default.
- W2005031444 cites W2127448926 @default.
- W2005031444 cites W2130294652 @default.
- W2005031444 cites W2137390873 @default.
- W2005031444 cites W2141938606 @default.
- W2005031444 cites W2145497832 @default.
- W2005031444 cites W2146842652 @default.
- W2005031444 cites W2151135812 @default.
- W2005031444 cites W2151463155 @default.
- W2005031444 cites W2152928608 @default.
- W2005031444 cites W2153563435 @default.
- W2005031444 cites W2155127310 @default.
- W2005031444 cites W2155897715 @default.
- W2005031444 cites W2162671646 @default.
- W2005031444 cites W2168147062 @default.
- W2005031444 cites W2170875861 @default.
- W2005031444 cites W2171116530 @default.
- W2005031444 cites W2262308156 @default.
- W2005031444 cites W2415130547 @default.
- W2005031444 cites W41401226 @default.