FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005034350> ?p ?o ?g. }

• W2005034350 endingPage "1202" @default.
• W2005034350 startingPage "1193" @default.
• W2005034350 abstract "Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50-80% of Brown Norway rats exposed to D-penicillamine develop an autoimmune syndrome after several weeks of treatment. The symptoms of the IDR are similar to that observed in humans who take D-penicillamine. The mechanism of this reaction is unknown, and no effective biomarkers have been identified to predict susceptibility. We postulate that cell stress caused by drugs is required to initiate the response. We used a high-throughput approach to identify factors that might represent danger signals by profiling hepatic gene expression 6 h after dosing with D-penicillamine (150 mg/kg). Our results show that the drug-treated animals cluster into two distinct groups. One group exhibits substantial expression changes relative to control animals. The most significantly altered transcripts have a role in stress, energy metabolism, acute phase response, and inflammation. We used quantitative reverse transcriptase polymerase chain reaction to measure transcript levels in liver biopsies of 33 rats and found that resistant animals cluster together. This resistant cluster of animals contains 87.5% (7/8) resistant animals but only 48% (12/25) sensitive animals. This separation is statistically significant at the p = 0.01 level." @default.
• W2005034350 created "2016-06-24" @default.
• W2005034350 creator A5007657275 @default.
• W2005034350 creator A5039008828 @default.
• W2005034350 creator A5040533778 @default.
• W2005034350 creator A5061777372 @default.
• W2005034350 creator A5070480313 @default.
• W2005034350 date "2005-07-01" @default.
• W2005034350 modified "2023-10-12" @default.
• W2005034350 title "Gene Expression Profiling in a Model of <scp>d</scp>-Penicillamine-Induced Autoimmunity in the Brown Norway Rat: Predictive Value of Early Signs of Danger" @default.
• W2005034350 cites W1566443303 @default.
• W2005034350 cites W1963967547 @default.
• W2005034350 cites W1967584222 @default.
• W2005034350 cites W1994226794 @default.
• W2005034350 cites W2014944550 @default.
• W2005034350 cites W2047882502 @default.
• W2005034350 cites W2055335169 @default.
• W2005034350 cites W2064208261 @default.
• W2005034350 cites W2066331200 @default.
• W2005034350 cites W2109327803 @default.
• W2005034350 cites W2109972881 @default.
• W2005034350 cites W2136066292 @default.
• W2005034350 cites W2144894933 @default.
• W2005034350 cites W2156106990 @default.
• W2005034350 cites W2170485407 @default.
• W2005034350 cites W4232412069 @default.
• W2005034350 cites W69050106 @default.
• W2005034350 doi "https://doi.org/10.1021/tx050040m" @default.
• W2005034350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16097792" @default.
• W2005034350 hasPublicationYear "2005" @default.
• W2005034350 type Work @default.
• W2005034350 sameAs 2005034350 @default.
• W2005034350 citedByCount "16" @default.
• W2005034350 countsByYear W20050343502012 @default.
• W2005034350 countsByYear W20050343502013 @default.
• W2005034350 countsByYear W20050343502017 @default.
• W2005034350 countsByYear W20050343502019 @default.
• W2005034350 crossrefType "journal-article" @default.
• W2005034350 hasAuthorship W2005034350A5007657275 @default.
• W2005034350 hasAuthorship W2005034350A5039008828 @default.
• W2005034350 hasAuthorship W2005034350A5040533778 @default.
• W2005034350 hasAuthorship W2005034350A5061777372 @default.
• W2005034350 hasAuthorship W2005034350A5070480313 @default.
• W2005034350 hasConcept C104317684 @default.
• W2005034350 hasConcept C126322002 @default.
• W2005034350 hasConcept C134018914 @default.
• W2005034350 hasConcept C150194340 @default.
• W2005034350 hasConcept C156719811 @default.
• W2005034350 hasConcept C18431079 @default.
• W2005034350 hasConcept C203014093 @default.
• W2005034350 hasConcept C2776914184 @default.
• W2005034350 hasConcept C2779348387 @default.
• W2005034350 hasConcept C2780035454 @default.
• W2005034350 hasConcept C2780130043 @default.
• W2005034350 hasConcept C49105822 @default.
• W2005034350 hasConcept C54355233 @default.
• W2005034350 hasConcept C71924100 @default.
• W2005034350 hasConcept C86803240 @default.
• W2005034350 hasConcept C8891405 @default.
• W2005034350 hasConcept C89311334 @default.
• W2005034350 hasConcept C98274493 @default.
• W2005034350 hasConceptScore W2005034350C104317684 @default.
• W2005034350 hasConceptScore W2005034350C126322002 @default.
• W2005034350 hasConceptScore W2005034350C134018914 @default.
• W2005034350 hasConceptScore W2005034350C150194340 @default.
• W2005034350 hasConceptScore W2005034350C156719811 @default.
• W2005034350 hasConceptScore W2005034350C18431079 @default.
• W2005034350 hasConceptScore W2005034350C203014093 @default.
• W2005034350 hasConceptScore W2005034350C2776914184 @default.
• W2005034350 hasConceptScore W2005034350C2779348387 @default.
• W2005034350 hasConceptScore W2005034350C2780035454 @default.
• W2005034350 hasConceptScore W2005034350C2780130043 @default.
• W2005034350 hasConceptScore W2005034350C49105822 @default.
• W2005034350 hasConceptScore W2005034350C54355233 @default.
• W2005034350 hasConceptScore W2005034350C71924100 @default.
• W2005034350 hasConceptScore W2005034350C86803240 @default.
• W2005034350 hasConceptScore W2005034350C8891405 @default.
• W2005034350 hasConceptScore W2005034350C89311334 @default.
• W2005034350 hasConceptScore W2005034350C98274493 @default.
• W2005034350 hasIssue "8" @default.
• W2005034350 hasLocation W20050343501 @default.
• W2005034350 hasLocation W20050343502 @default.
• W2005034350 hasOpenAccess W2005034350 @default.
• W2005034350 hasPrimaryLocation W20050343501 @default.
• W2005034350 hasRelatedWork W1640165957 @default.
• W2005034350 hasRelatedWork W167219501 @default.
• W2005034350 hasRelatedWork W2019425800 @default.
• W2005034350 hasRelatedWork W2080518293 @default.
• W2005034350 hasRelatedWork W2157284704 @default.
• W2005034350 hasRelatedWork W2195790131 @default.
• W2005034350 hasRelatedWork W2412718868 @default.
• W2005034350 hasRelatedWork W2417403314 @default.
• W2005034350 hasRelatedWork W2461769281 @default.
• W2005034350 hasRelatedWork W3105232760 @default.
• W2005034350 hasVolume "18" @default.
• W2005034350 isParatext "false" @default.
• W2005034350 isRetracted "false" @default.
• W2005034350 magId "2005034350" @default.

• next