Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005035523> ?p ?o ?g. }
- W2005035523 endingPage "9" @default.
- W2005035523 startingPage "1" @default.
- W2005035523 abstract "Dopamine (DA) deficiency is one of the primary lesions in the pathogenesis of Parkinson disease (PD). Because of long-term toxicity of L-DOPA therapy, the grafting of fetal mesencephalic tissue containing dopamine neurons or homogeneous populations of DA neurons into striatum appears to be rational. Fetal tissue transplants have many problems which include legal (in some countries), ethical, paucity of tissue availability, heterogenicity of cell populations, and the presence of antigen-presenting cells that are responsible for rejection of allogeneic grafts. In order to resolve the above problems, we have established immortalized DA neurons from fetal rat mesencephalon by inserting the large T-antigen (LTa) gene of the SV40 virus into the cells. A clone of DA neurons (1RB3AN27) was isolated, characterized, and tested in 6-hydroxydopamine (6-OHDA)-lesioned rats (a model of PD). These cells divided with a doubling time of about 26 h, expressed the LTa gene, and contained the tyrosine hydroxylase and dopamine transporter proteins and their respective mRNAs, which became elevated upon differentiation. These cells were nontumorigenic and nonimmunogenic and improved the symptoms of neurological deficits (methamphetamine-induced rotation) in 6-OHDA-lesioned rats. The differentiated DA neurons were more effective than undifferentiated ones. These studies suggest that immortalized DA neurons generated in vitro by LTa gene insertion may be used in transplant therapy without fear of tumor formation or rejection." @default.
- W2005035523 created "2016-06-24" @default.
- W2005035523 creator A5001277165 @default.
- W2005035523 creator A5008526392 @default.
- W2005035523 creator A5027671594 @default.
- W2005035523 creator A5052388621 @default.
- W2005035523 creator A5071776637 @default.
- W2005035523 date "1998-09-01" @default.
- W2005035523 modified "2023-10-09" @default.
- W2005035523 title "Efficacy of Grafted Immortalized Dopamine Neurons in an Animal Model of Parkinsonism: A Review" @default.
- W2005035523 cites W1594259755 @default.
- W2005035523 cites W1965340376 @default.
- W2005035523 cites W1974338408 @default.
- W2005035523 cites W1974400678 @default.
- W2005035523 cites W1974824455 @default.
- W2005035523 cites W1980823466 @default.
- W2005035523 cites W1984767115 @default.
- W2005035523 cites W1986592378 @default.
- W2005035523 cites W1987203624 @default.
- W2005035523 cites W1989934989 @default.
- W2005035523 cites W1989964231 @default.
- W2005035523 cites W1997008745 @default.
- W2005035523 cites W2008001474 @default.
- W2005035523 cites W2014508565 @default.
- W2005035523 cites W2015500392 @default.
- W2005035523 cites W2017138388 @default.
- W2005035523 cites W2024683111 @default.
- W2005035523 cites W2024877723 @default.
- W2005035523 cites W2026508306 @default.
- W2005035523 cites W2031324202 @default.
- W2005035523 cites W2033300138 @default.
- W2005035523 cites W2035421391 @default.
- W2005035523 cites W2035910821 @default.
- W2005035523 cites W2036564942 @default.
- W2005035523 cites W2042817821 @default.
- W2005035523 cites W2044549900 @default.
- W2005035523 cites W2051028088 @default.
- W2005035523 cites W2052956756 @default.
- W2005035523 cites W2053671087 @default.
- W2005035523 cites W2058886637 @default.
- W2005035523 cites W2065564530 @default.
- W2005035523 cites W2066248702 @default.
- W2005035523 cites W2069170243 @default.
- W2005035523 cites W2070679671 @default.
- W2005035523 cites W2072908309 @default.
- W2005035523 cites W2074692684 @default.
- W2005035523 cites W2085593741 @default.
- W2005035523 cites W2088446090 @default.
- W2005035523 cites W2089683266 @default.
- W2005035523 cites W2100336169 @default.
- W2005035523 cites W2106215239 @default.
- W2005035523 cites W2130269221 @default.
- W2005035523 cites W2131608302 @default.
- W2005035523 cites W2135730012 @default.
- W2005035523 cites W2139132468 @default.
- W2005035523 cites W2153813109 @default.
- W2005035523 cites W2161384798 @default.
- W2005035523 cites W2162679852 @default.
- W2005035523 cites W2162756370 @default.
- W2005035523 cites W2175315782 @default.
- W2005035523 cites W2331652887 @default.
- W2005035523 cites W2337142316 @default.
- W2005035523 cites W2413583766 @default.
- W2005035523 cites W2418755946 @default.
- W2005035523 cites W2794935492 @default.
- W2005035523 doi "https://doi.org/10.1006/mgme.1998.2726" @default.
- W2005035523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9787089" @default.
- W2005035523 hasPublicationYear "1998" @default.
- W2005035523 type Work @default.
- W2005035523 sameAs 2005035523 @default.
- W2005035523 citedByCount "41" @default.
- W2005035523 countsByYear W20050355232012 @default.
- W2005035523 countsByYear W20050355232013 @default.
- W2005035523 countsByYear W20050355232014 @default.
- W2005035523 countsByYear W20050355232015 @default.
- W2005035523 countsByYear W20050355232016 @default.
- W2005035523 countsByYear W20050355232019 @default.
- W2005035523 countsByYear W20050355232022 @default.
- W2005035523 crossrefType "journal-article" @default.
- W2005035523 hasAuthorship W2005035523A5001277165 @default.
- W2005035523 hasAuthorship W2005035523A5008526392 @default.
- W2005035523 hasAuthorship W2005035523A5027671594 @default.
- W2005035523 hasAuthorship W2005035523A5052388621 @default.
- W2005035523 hasAuthorship W2005035523A5071776637 @default.
- W2005035523 hasConcept C137183658 @default.
- W2005035523 hasConcept C142724271 @default.
- W2005035523 hasConcept C159167319 @default.
- W2005035523 hasConcept C169760540 @default.
- W2005035523 hasConcept C2776525014 @default.
- W2005035523 hasConcept C2776755682 @default.
- W2005035523 hasConcept C2779134260 @default.
- W2005035523 hasConcept C2780062018 @default.
- W2005035523 hasConcept C2780376393 @default.
- W2005035523 hasConcept C513476851 @default.
- W2005035523 hasConcept C71924100 @default.
- W2005035523 hasConcept C86803240 @default.
- W2005035523 hasConcept C95444343 @default.
- W2005035523 hasConcept C98274493 @default.