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- W2005037059 abstract "Abstract Changes of monoamine oxidase (MAO) activity in heart, mesenteric artery, and aorta of young (6 weeks old) and aged (24 months old) rats were measured using serotonin, a substrate for type A MAO, and 2-phenylethylamine, a substrate for type B MAO. The heart of the aged animals showed increased activity of both enzyme types. Serotonin deamination was increased six-fold and 2-phenylethylamine deamination eleven-fold over values for young rats. In contrast to heart, the deamination of both amines was decreased in the vessels of the aged rats. Serotonin deamination declined by over twelve-fold in mesenteric artery and six-fold in aorta. 2-Phenylethylamine deamination in vessels was decreased to 36 and 55% of the values found for young rats for mesenteric artery and aorta, respectively. Type A enzyme, which is found primarily in sympathetic nerve endings of vessels, inactivates the biogenic amines and loss of this enzyme in the vasculature may play a role in increased blood pressure in senescence. Moreover, the decline of type A activity in the aged animals may reflect a decrease in the density of sympathetic neurons innervating the vasculature, or perhaps an age-related alteration in the metabolic properties of sympathetic nerve endings." @default.
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- W2005037059 date "1977-01-01" @default.
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- W2005037059 title "Monoamine oxidase activity in the cardiovascular system of young and aged rats" @default.
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- W2005037059 doi "https://doi.org/10.1016/0531-5565(77)90018-3" @default.
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