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• W2005040820 abstract "The marine metabolites pacifenol, stypotriol triacetate and epitaondiol were tested for their effects on a number of inflammatory responses. Epitaondiol exhibited a potent topical anti-inflammatory activity related to inhibition of leukocyte accumulation. The other compounds showed a lower potency, similar to that of indomethacin. None of the compounds affected superoxide generation by human neutrophils but pacifenol effectively inhibited the degranulation response. This compound and epitaondiol decreased the release of eicosanoids with a higher potency on the cyclo-oxygenase pathway. Only epitaondiol inhibited human recombinant synovial phospholipase A2 activity in a concentration-dependent manner." @default.
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• W2005040820 date "1995-06-01" @default.
• W2005040820 modified "2023-10-14" @default.
• W2005040820 title "Inhibition of inflammatory responses by epitaondiol and other marine natural products" @default.
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• W2005040820 doi "https://doi.org/10.1016/0024-3205(95)00260-d" @default.
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