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• W2005040852 abstract "8-(Sulfostyryl)xanthine derivatives were synthesized as water-soluble A2A-selective adenosine receptor (AR) antagonists. meta- and para-sulfostyryl-DMPX (3,7-dimethyl-1-propargylxanthine) derivatives 11a and 11b exhibited high affinity to rat A2A-AR in submicromolar concentrations, and were 20- to 30-fold selective versus rat A1-AR. Styryl-DMPX derivatives were inactive at human A2B- and A3-AR. 1,3-Dipropyl-8-p-sulfostyrylxanthine (13) and its 7-methyl derivative (14) showed similar (13) or higher (14) A2A affinity than 11a and 11b but showed no (13) or only a low degree (14) of selectivity versus A1-, A2B-, and A3-AR. The A2A-selective sulfostyryl-DMPX derivatives exhibit high water-solubility and may be useful research tools for in vivo studies." @default.
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• W2005040852 date "1998-06-01" @default.
• W2005040852 modified "2023-10-16" @default.
• W2005040852 title "8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists11Preliminary results were presented at the International Symposium “Purines ’96” in Milan, Italy; abstract published in Drug Dev. Res. 1996, 37, 112." @default.
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• W2005040852 doi "https://doi.org/10.1016/s0968-0896(98)00025-x" @default.
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