FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005043359> ?p ?o ?g. }

• W2005043359 endingPage "50" @default.
• W2005043359 startingPage "43" @default.
• W2005043359 abstract "Abstract— Photodynamic therapy (PDT) of cancer combines irradiation of tumors with visible light following selective uptake of the photosensitizer by the tumor cells. PhotofrinR-II (Pf-II) is the only photosensitizer which is in clinical use in PDT, whereas chloroaluminum phthalocyanine tetrasulfonate (AIPcTS) has also shown promise in preclinical studies. In most such studies, the effectiveness of the photosensitizers has been assessed in implanted tumor model systems rather than in model systems where tumors are allowed to grow in their own connective tissue matrix. In this study the pharmacoki-netics, tumor ablation capability and cutaneous photosensitization response of AlPcTS have been assessed in mice bearing chemically- and ultraviolet B radiation (UVB)-induced benign skin papillomas. When tumor-bearing animals were injected intraperitoneally with AlPcTS (5 mg/kg body wt), maximum tumor:normal skin ratio of 2.4 was observed at 48 h, at which time the mice were irradiated within the absorption spectrum of the photosensitizer. In tumor ablation studies with SENCAR mice bearing chemically-induced skin tumors, AlPcTS resulted in greater than 80% ablation in tumor volume at 20 days post-irradiation. In cutaneous photosensitization response, AlPcTS produced only transient effects (no effect after 24 h) in SENCAR mice. Pharmacokinetics data, tumor ablation effects and cutaneous photosensitization response of AlPcTS were comparable in SKH-1 hairless mice bearing UVB-induced skin tumors. Our data indicate that AlPcTS produces significant photodynamic effects towards the ablation of murine skin tumors, and that it does not produce prolonged cutaneous photosensitivity." @default.
• W2005043359 created "2016-06-24" @default.
• W2005043359 creator A5048444823 @default.
• W2005043359 creator A5051982352 @default.
• W2005043359 creator A5076875729 @default.
• W2005043359 creator A5079917691 @default.
• W2005043359 creator A5082425428 @default.
• W2005043359 date "1992-07-01" @default.
• W2005043359 modified "2023-09-26" @default.
• W2005043359 title "PHOTODYNAMIC THERAPY OF CHEMICALLY- AND ULTRAVIOLET B RADIATION-INDUCED MURINE SKIN PAPILLOMAS BY CHLOROALUMINUM PHTHALOCYANINE TETRASULFONATE" @default.
• W2005043359 cites W1965405925 @default.
• W2005043359 cites W1965514362 @default.
• W2005043359 cites W1966146579 @default.
• W2005043359 cites W1980817526 @default.
• W2005043359 cites W1980954908 @default.
• W2005043359 cites W1988600705 @default.
• W2005043359 cites W1996180232 @default.
• W2005043359 cites W1997549721 @default.
• W2005043359 cites W2003404904 @default.
• W2005043359 cites W2014506753 @default.
• W2005043359 cites W2015294260 @default.
• W2005043359 cites W2016729734 @default.
• W2005043359 cites W2020330535 @default.
• W2005043359 cites W2028224679 @default.
• W2005043359 cites W2029329212 @default.
• W2005043359 cites W2030202421 @default.
• W2005043359 cites W2030788074 @default.
• W2005043359 cites W2041070700 @default.
• W2005043359 cites W2045415112 @default.
• W2005043359 cites W2048303522 @default.
• W2005043359 cites W2048928608 @default.
• W2005043359 cites W2052150782 @default.
• W2005043359 cites W2052870565 @default.
• W2005043359 cites W2056425856 @default.
• W2005043359 cites W2059689137 @default.
• W2005043359 cites W2061315595 @default.
• W2005043359 cites W2076269924 @default.
• W2005043359 cites W2076682216 @default.
• W2005043359 cites W2087404609 @default.
• W2005043359 cites W2091448607 @default.
• W2005043359 cites W2093738511 @default.
• W2005043359 cites W2094634030 @default.
• W2005043359 cites W2098327327 @default.
• W2005043359 cites W2099264021 @default.
• W2005043359 cites W2113464733 @default.
• W2005043359 cites W2123483305 @default.
• W2005043359 cites W2135256408 @default.
• W2005043359 cites W2140210736 @default.
• W2005043359 cites W2167356190 @default.
• W2005043359 cites W2325628170 @default.
• W2005043359 cites W2396847665 @default.
• W2005043359 doi "https://doi.org/10.1111/j.1751-1097.1992.tb09600.x" @default.
• W2005043359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1508981" @default.
• W2005043359 hasPublicationYear "1992" @default.
• W2005043359 type Work @default.
• W2005043359 sameAs 2005043359 @default.
• W2005043359 citedByCount "27" @default.
• W2005043359 countsByYear W20050433592013 @default.
• W2005043359 countsByYear W20050433592015 @default.
• W2005043359 countsByYear W20050433592018 @default.
• W2005043359 countsByYear W20050433592019 @default.
• W2005043359 countsByYear W20050433592021 @default.
• W2005043359 crossrefType "journal-article" @default.
• W2005043359 hasAuthorship W2005043359A5048444823 @default.
• W2005043359 hasAuthorship W2005043359A5051982352 @default.
• W2005043359 hasAuthorship W2005043359A5076875729 @default.
• W2005043359 hasAuthorship W2005043359A5079917691 @default.
• W2005043359 hasAuthorship W2005043359A5082425428 @default.
• W2005043359 hasConcept C121608353 @default.
• W2005043359 hasConcept C12554922 @default.
• W2005043359 hasConcept C126322002 @default.
• W2005043359 hasConcept C142724271 @default.
• W2005043359 hasConcept C178790620 @default.
• W2005043359 hasConcept C185592680 @default.
• W2005043359 hasConcept C186807665 @default.
• W2005043359 hasConcept C192562407 @default.
• W2005043359 hasConcept C202751555 @default.
• W2005043359 hasConcept C20639190 @default.
• W2005043359 hasConcept C2777459323 @default.
• W2005043359 hasConcept C2777789703 @default.
• W2005043359 hasConcept C2778178086 @default.
• W2005043359 hasConcept C2779156968 @default.
• W2005043359 hasConcept C2781323092 @default.
• W2005043359 hasConcept C2781469039 @default.
• W2005043359 hasConcept C49040817 @default.
• W2005043359 hasConcept C502942594 @default.
• W2005043359 hasConcept C54355233 @default.
• W2005043359 hasConcept C55493867 @default.
• W2005043359 hasConcept C71924100 @default.
• W2005043359 hasConcept C75473681 @default.
• W2005043359 hasConcept C86803240 @default.
• W2005043359 hasConceptScore W2005043359C121608353 @default.
• W2005043359 hasConceptScore W2005043359C12554922 @default.
• W2005043359 hasConceptScore W2005043359C126322002 @default.
• W2005043359 hasConceptScore W2005043359C142724271 @default.
• W2005043359 hasConceptScore W2005043359C178790620 @default.
• W2005043359 hasConceptScore W2005043359C185592680 @default.
• W2005043359 hasConceptScore W2005043359C186807665 @default.

• next