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- W2005045904 abstract "Colonoscopy is the mainstay of colorectal cancer prevention but only provides partial protection. Current endoscopic techniques miss up to 25% of polyps. Combining targeted molecular probes and advanced imaging technology could serve as a ‘red flag’ technique to facilitate polyp detection. c-Met overexpression occurs early in the colorectal adenoma-carcinoma sequence and was therefore selected as a biomarker for colonic neoplasia.We report the development and first results in patients of a new intravenously administered molecular imaging probe. The probe consists of a water soluble 26-amino acid cyclic peptide labelled with a fluorescent cyanine dye and developed for use in conjunction with a prototype dual white-light (WL) and near infra-red fluorescent-light (FL) endoscopic imaging system consisting of a modified Pentax FC 38LV fibre colonoscope. The peptide was isolated by phage display based on its ability to bind the extracellular domain of c-Met while not competing with HGF. It has high affinity for human c-Met (Kd = 2nM) with no effects on downstream signalling." @default.
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- W2005045904 date "2013-05-01" @default.
- W2005045904 modified "2023-09-27" @default.
- W2005045904 title "701 Detection of Colonic Neoplasia In Vivo in Humans Using an Intravenously Administered Fluorescent Peptide Targeted Against C-MET and Fluorescent Colonoscopy" @default.
- W2005045904 doi "https://doi.org/10.1016/j.gie.2013.04.104" @default.
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