Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005047079> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2005047079 endingPage "3297" @default.
- W2005047079 startingPage "3290" @default.
- W2005047079 abstract "ABSTRACT The OqxAB efflux pump, a plasmid-mediated quinolone resistance (PMQR) determinant, has become increasingly prevalent among members of Enterobacteriaceae over the past decade. To investigate the evolution and dissemination routes of the oqxAB operon, we assessed the prevalence of oqxAB -like elements among various Gram-negative bacterial species and analyzed the genotypic and phenotypic characteristics of organisms harboring such elements. With a comprehensive genotyping approach, a chromosome-based oqxAB operon was detectable in all Klebsiella pneumoniae strains tested, including organisms isolated before the year 1984. Sequence and phylogenetic analyses confirmed that the oqxAB operon in K. pneumoniae isolates was genetically closest to their plasmid-borne counterparts recoverable only from Escherichia coli and Salmonella isolates collected from the year 2003 onward. Chromosomal elements with much lower sequence homology were also found among the Enterobacter spp. but not other Gram-negative species. Contrary to the quinolone resistance phenotypes which were consistently observable among organisms with oqxAB -harboring plasmids, chromosomal oqxAB elements generally did not confer quinolone resistance, except for K. pneumoniae strains, which exhibited a typical oqxAB -mediated phenotype characterized by cross-resistance to olaquindox, chloramphenicol, and the quinolones. Gene expression analysis illustrated that such phenotypes were due to elevated expression of the chromosomal oqxAB operon. Furthermore, transposition of the oqxAB operon from the bacterial chromosome to plasmids was found to result in a >80-fold increase in the level of expression of the OqxAB pump, confirming its status as the first constitutively expressed efflux system located in bacterial mobile elements." @default.
- W2005047079 created "2016-06-24" @default.
- W2005047079 creator A5024582456 @default.
- W2005047079 creator A5059057094 @default.
- W2005047079 creator A5063907482 @default.
- W2005047079 date "2015-06-01" @default.
- W2005047079 modified "2023-10-14" @default.
- W2005047079 title "Evolution and Dissemination of OqxAB-Like Efflux Pumps, an Emerging Quinolone Resistance Determinant among Members of Enterobacteriaceae" @default.
- W2005047079 cites W1987631813 @default.
- W2005047079 cites W2057708061 @default.
- W2005047079 cites W2057802951 @default.
- W2005047079 cites W2074371039 @default.
- W2005047079 cites W2082424449 @default.
- W2005047079 cites W2101862832 @default.
- W2005047079 cites W2106399625 @default.
- W2005047079 cites W2120998206 @default.
- W2005047079 cites W2124504929 @default.
- W2005047079 cites W2133221340 @default.
- W2005047079 cites W2136119932 @default.
- W2005047079 cites W2136871577 @default.
- W2005047079 cites W2152207030 @default.
- W2005047079 cites W2155478352 @default.
- W2005047079 cites W2170967608 @default.
- W2005047079 doi "https://doi.org/10.1128/aac.00310-15" @default.
- W2005047079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4432112" @default.
- W2005047079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25801572" @default.
- W2005047079 hasPublicationYear "2015" @default.
- W2005047079 type Work @default.
- W2005047079 sameAs 2005047079 @default.
- W2005047079 citedByCount "53" @default.
- W2005047079 countsByYear W20050470792015 @default.
- W2005047079 countsByYear W20050470792016 @default.
- W2005047079 countsByYear W20050470792017 @default.
- W2005047079 countsByYear W20050470792018 @default.
- W2005047079 countsByYear W20050470792019 @default.
- W2005047079 countsByYear W20050470792020 @default.
- W2005047079 countsByYear W20050470792021 @default.
- W2005047079 countsByYear W20050470792022 @default.
- W2005047079 countsByYear W20050470792023 @default.
- W2005047079 crossrefType "journal-article" @default.
- W2005047079 hasAuthorship W2005047079A5024582456 @default.
- W2005047079 hasAuthorship W2005047079A5059057094 @default.
- W2005047079 hasAuthorship W2005047079A5063907482 @default.
- W2005047079 hasBestOaLocation W20050470791 @default.
- W2005047079 hasConcept C104317684 @default.
- W2005047079 hasConcept C200082930 @default.
- W2005047079 hasConcept C203075996 @default.
- W2005047079 hasConcept C22744801 @default.
- W2005047079 hasConcept C2777058267 @default.
- W2005047079 hasConcept C2778910516 @default.
- W2005047079 hasConcept C2779922871 @default.
- W2005047079 hasConcept C501593827 @default.
- W2005047079 hasConcept C54355233 @default.
- W2005047079 hasConcept C547475151 @default.
- W2005047079 hasConcept C86803240 @default.
- W2005047079 hasConcept C89423630 @default.
- W2005047079 hasConceptScore W2005047079C104317684 @default.
- W2005047079 hasConceptScore W2005047079C200082930 @default.
- W2005047079 hasConceptScore W2005047079C203075996 @default.
- W2005047079 hasConceptScore W2005047079C22744801 @default.
- W2005047079 hasConceptScore W2005047079C2777058267 @default.
- W2005047079 hasConceptScore W2005047079C2778910516 @default.
- W2005047079 hasConceptScore W2005047079C2779922871 @default.
- W2005047079 hasConceptScore W2005047079C501593827 @default.
- W2005047079 hasConceptScore W2005047079C54355233 @default.
- W2005047079 hasConceptScore W2005047079C547475151 @default.
- W2005047079 hasConceptScore W2005047079C86803240 @default.
- W2005047079 hasConceptScore W2005047079C89423630 @default.
- W2005047079 hasIssue "6" @default.
- W2005047079 hasLocation W20050470791 @default.
- W2005047079 hasLocation W20050470792 @default.
- W2005047079 hasLocation W20050470793 @default.
- W2005047079 hasLocation W20050470794 @default.
- W2005047079 hasOpenAccess W2005047079 @default.
- W2005047079 hasPrimaryLocation W20050470791 @default.
- W2005047079 hasRelatedWork W1982073117 @default.
- W2005047079 hasRelatedWork W1997028496 @default.
- W2005047079 hasRelatedWork W2010069081 @default.
- W2005047079 hasRelatedWork W2066829323 @default.
- W2005047079 hasRelatedWork W2086586424 @default.
- W2005047079 hasRelatedWork W2172172881 @default.
- W2005047079 hasRelatedWork W2525602183 @default.
- W2005047079 hasRelatedWork W2616295139 @default.
- W2005047079 hasRelatedWork W2911633514 @default.
- W2005047079 hasRelatedWork W4361191013 @default.
- W2005047079 hasVolume "59" @default.
- W2005047079 isParatext "false" @default.
- W2005047079 isRetracted "false" @default.
- W2005047079 magId "2005047079" @default.
- W2005047079 workType "article" @default.