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• W2005048359 abstract "A dimeric 40-kDa Kunitz-type trypsin inhibitor was isolated from seeds of the Chinese black soybean Glycine max cv. ‘Dull Black’. The purification protocol comprised ion exchange chromatography on Q-Sepharose, SP-Sepharose, and Mono Q, and gel filtration on Superdex 75. The trypsin inhibitor inhibited chymotrypsin, albeit to a lesser extent than it inhibited trypsin. Its trypsin-inhibitory activity was unaffected after exposure to pH 1–14, or to temperatures up to 80 °C. The trypsin inhibitor was inhibited by dithiothreitol in a dose-dependent (from 2.5 to 50 mM) and a time-dependent (from 5 to 120 min) manner. Besides inhibiting serine proteases, the trypsin inhibitor demonstrated additional biological activities including stimulation of nitric oxide production by macrophages. It inhibited HIV-1 reverse transcriptase, cell-free translation and proliferation of liver cancer cells and breast cancer cells, with an IC50 value 9.4, 14, 39 and 70 μM, respectively. However, it did not exhibit antifungal, antibacterial or mitogenic activity." @default.
• W2005048359 created "2016-06-24" @default.
• W2005048359 creator A5033631664 @default.
• W2005048359 creator A5035780833 @default.
• W2005048359 date "2008-09-01" @default.
• W2005048359 modified "2023-09-27" @default.
• W2005048359 title "A stable trypsin inhibitor from Chinese dull black soybeans with potentially exploitable activities" @default.
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• W2005048359 doi "https://doi.org/10.1016/j.procbio.2008.05.005" @default.
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