Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005048924> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2005048924 endingPage "422" @default.
- W2005048924 startingPage "418" @default.
- W2005048924 abstract "Abstract Copolymers of N ‐isopropylacrylamide (NIPAAm), 2‐hydroxyethyl methacryl lactate (HEMA‐lactate) and acrylic acid (AAc) were prepared, with varying mole ratios of monomers, to develop a bioresorbable in‐situ ‐gelling material with a time‐dependent lower critical solution temperature (LCST). The synthesized copolymers were characterized by nuclear magnetic resonance, gel permeation chromatography and differential scanning calorimetry. In 0.1 M phosphate‐buffered saline solution of pH 7.4, these copolymers had an LCST below body temperature. The LCST decreased as the HEMA‐lactate content of the copolymers was increased. Furthermore, in these conditions, the LCST of the copolymers exhibited time‐dependent properties, due to hydrolysis of the HEMA‐lactate. As the HEMA‐lactate hydrolyzed, the copolymers became more hydrophilic, thereby leading to an increase in LCST. This hydrophilicity caused copolymers of approximately 6 mol% of AAc to exhibit an LCST above body temperature after hydrolysis. In neutral solution, copolymers with varying mol% of AAc saw their LCST rise above 37 °C within one to ten days, depending upon the HEMA‐lactate/NIPAAm ratio, due to the complete hydrolysis of the HEMA‐lactate. The above properties indicate that these copolymers would be useful for drug delivery because their variable LCST makes them bioresorbable. Copyright © 2004 Society of Chemical Industry" @default.
- W2005048924 created "2016-06-24" @default.
- W2005048924 creator A5038309111 @default.
- W2005048924 creator A5071272939 @default.
- W2005048924 date "2004-12-06" @default.
- W2005048924 modified "2023-10-10" @default.
- W2005048924 title "Copolymers ofN-isopropylacrylamide, HEMA-lactate and acrylic acid with time-dependent lower critical solution temperature as a bioresorbable carrier" @default.
- W2005048924 cites W1800156099 @default.
- W2005048924 cites W1974371653 @default.
- W2005048924 cites W1981866155 @default.
- W2005048924 cites W2001786338 @default.
- W2005048924 cites W2005150737 @default.
- W2005048924 cites W2009328092 @default.
- W2005048924 cites W2023989058 @default.
- W2005048924 cites W2029455834 @default.
- W2005048924 cites W2030141189 @default.
- W2005048924 cites W2031822553 @default.
- W2005048924 cites W2042948347 @default.
- W2005048924 cites W2048240452 @default.
- W2005048924 cites W2055830673 @default.
- W2005048924 cites W2059072573 @default.
- W2005048924 cites W2078590536 @default.
- W2005048924 cites W2084708892 @default.
- W2005048924 cites W2118750977 @default.
- W2005048924 cites W4362107866 @default.
- W2005048924 doi "https://doi.org/10.1002/pi.1709" @default.
- W2005048924 hasPublicationYear "2004" @default.
- W2005048924 type Work @default.
- W2005048924 sameAs 2005048924 @default.
- W2005048924 citedByCount "44" @default.
- W2005048924 countsByYear W20050489242012 @default.
- W2005048924 countsByYear W20050489242013 @default.
- W2005048924 countsByYear W20050489242014 @default.
- W2005048924 countsByYear W20050489242015 @default.
- W2005048924 countsByYear W20050489242016 @default.
- W2005048924 countsByYear W20050489242017 @default.
- W2005048924 countsByYear W20050489242019 @default.
- W2005048924 countsByYear W20050489242020 @default.
- W2005048924 countsByYear W20050489242021 @default.
- W2005048924 countsByYear W20050489242022 @default.
- W2005048924 crossrefType "journal-article" @default.
- W2005048924 hasAuthorship W2005048924A5038309111 @default.
- W2005048924 hasAuthorship W2005048924A5071272939 @default.
- W2005048924 hasConcept C121332964 @default.
- W2005048924 hasConcept C15920480 @default.
- W2005048924 hasConcept C178790620 @default.
- W2005048924 hasConcept C185592680 @default.
- W2005048924 hasConcept C188027245 @default.
- W2005048924 hasConcept C188109995 @default.
- W2005048924 hasConcept C192562407 @default.
- W2005048924 hasConcept C2776892847 @default.
- W2005048924 hasConcept C2780503075 @default.
- W2005048924 hasConcept C39519442 @default.
- W2005048924 hasConcept C521977710 @default.
- W2005048924 hasConcept C94412978 @default.
- W2005048924 hasConcept C97355855 @default.
- W2005048924 hasConceptScore W2005048924C121332964 @default.
- W2005048924 hasConceptScore W2005048924C15920480 @default.
- W2005048924 hasConceptScore W2005048924C178790620 @default.
- W2005048924 hasConceptScore W2005048924C185592680 @default.
- W2005048924 hasConceptScore W2005048924C188027245 @default.
- W2005048924 hasConceptScore W2005048924C188109995 @default.
- W2005048924 hasConceptScore W2005048924C192562407 @default.
- W2005048924 hasConceptScore W2005048924C2776892847 @default.
- W2005048924 hasConceptScore W2005048924C2780503075 @default.
- W2005048924 hasConceptScore W2005048924C39519442 @default.
- W2005048924 hasConceptScore W2005048924C521977710 @default.
- W2005048924 hasConceptScore W2005048924C94412978 @default.
- W2005048924 hasConceptScore W2005048924C97355855 @default.
- W2005048924 hasIssue "2" @default.
- W2005048924 hasLocation W20050489241 @default.
- W2005048924 hasOpenAccess W2005048924 @default.
- W2005048924 hasPrimaryLocation W20050489241 @default.
- W2005048924 hasRelatedWork W1969497608 @default.
- W2005048924 hasRelatedWork W2006631374 @default.
- W2005048924 hasRelatedWork W2019059560 @default.
- W2005048924 hasRelatedWork W2031076312 @default.
- W2005048924 hasRelatedWork W2045220775 @default.
- W2005048924 hasRelatedWork W2339751706 @default.
- W2005048924 hasRelatedWork W2356954898 @default.
- W2005048924 hasRelatedWork W2367854611 @default.
- W2005048924 hasRelatedWork W2388091995 @default.
- W2005048924 hasRelatedWork W4313407448 @default.
- W2005048924 hasVolume "54" @default.
- W2005048924 isParatext "false" @default.
- W2005048924 isRetracted "false" @default.
- W2005048924 magId "2005048924" @default.
- W2005048924 workType "article" @default.