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- W2005048958 abstract "Forming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion of the Wnt ligand EGL-20 from cells in the tail and partially the result of neuronal action. MTM-6 shows relative specificity for EGL-20 over the other Wnt ligands. We suggest that the ability of MTM-6 to regulate EGL-20 secretion is a function of its expression pattern. We conclude that regulation of secretion of different Wnt ligands can use different components. Additionally, we present a novel neuronal function for MTM-6." @default.
- W2005048958 created "2016-06-24" @default.
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- W2005048958 date "2014-12-05" @default.
- W2005048958 modified "2023-10-16" @default.
- W2005048958 title "MTM-6, a Phosphoinositide Phosphatase, is Required to Promote Synapse Formation in Caenorhabditis elegans" @default.
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- W2005048958 doi "https://doi.org/10.1371/journal.pone.0114501" @default.
- W2005048958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4257696" @default.
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