FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005048971> ?p ?o ?g. }

• W2005048971 endingPage "386" @default.
• W2005048971 startingPage "381" @default.
• W2005048971 abstract "The subcutaneous administration of a single dose of an opiate agonist (levorphanol) or antagonist (naloxone) to guinea pigs results in an at least 3-fold elevation of dynorphin and alpha-neoendorphin-immunoreactivity in the longitudinal muscle myenteric plexus preparation. The effects are time- and dose-dependent, significant elevations first being observed 6 h after treatment and lasting for up to 24 h. Pretreatment levels of opioid peptides were observed after 8 days. Combined injection of the narcotic agonist and antagonist, at sufficiently high doses, resulted in an additive effect of the individual drugs. The respective stereoisomers dextrorphan and (+)-naloxone did not affect prodynorphin-derived peptide concentrations. An increase of endogenous opioids was also observed after administration of the nonopiate clonidine, a compound which, like opiates, alters the activity of the myenteric plexus. It is suggested that feedback mechanisms in the myenteric plexus are responsible for the elevation of endogenous opioid peptides following exposure to exogenous opiates. Using a monoclonal antibody (3-E7), which recognizes virtually all endogenous opioid peptides, it was found that levels of higher molecular material were also increased upon opiate challenge. This suggests that a single dose of an exogenous opiate results in an increase in peptide synthesis." @default.
• W2005048971 created "2016-06-24" @default.
• W2005048971 creator A5022578733 @default.
• W2005048971 creator A5023094099 @default.
• W2005048971 creator A5052975327 @default.
• W2005048971 creator A5086202312 @default.
• W2005048971 date "1986-08-01" @default.
• W2005048971 modified "2023-10-15" @default.
• W2005048971 title "Opiates induce long-term increases in prodynorphin-derived peptide levels in the guinea-pig myenteric plexus" @default.
• W2005048971 cites W1504804626 @default.
• W2005048971 cites W1582530932 @default.
• W2005048971 cites W1789439462 @default.
• W2005048971 cites W1870867636 @default.
• W2005048971 cites W1974622659 @default.
• W2005048971 cites W1978921076 @default.
• W2005048971 cites W1980910144 @default.
• W2005048971 cites W1996315197 @default.
• W2005048971 cites W2005136130 @default.
• W2005048971 cites W2033680879 @default.
• W2005048971 cites W2033814096 @default.
• W2005048971 cites W2042908459 @default.
• W2005048971 cites W2046809670 @default.
• W2005048971 cites W2047487968 @default.
• W2005048971 cites W2050569442 @default.
• W2005048971 cites W2057533581 @default.
• W2005048971 cites W2066040150 @default.
• W2005048971 cites W2070538263 @default.
• W2005048971 cites W2081832794 @default.
• W2005048971 cites W2090085845 @default.
• W2005048971 cites W2121790796 @default.
• W2005048971 cites W2132424649 @default.
• W2005048971 cites W2157070224 @default.
• W2005048971 cites W2172323892 @default.
• W2005048971 cites W2413307545 @default.
• W2005048971 cites W2887419848 @default.
• W2005048971 doi "https://doi.org/10.1007/bf00500013" @default.
• W2005048971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3774018" @default.
• W2005048971 hasPublicationYear "1986" @default.
• W2005048971 type Work @default.
• W2005048971 sameAs 2005048971 @default.
• W2005048971 citedByCount "9" @default.
• W2005048971 crossrefType "journal-article" @default.
• W2005048971 hasAuthorship W2005048971A5022578733 @default.
• W2005048971 hasAuthorship W2005048971A5023094099 @default.
• W2005048971 hasAuthorship W2005048971A5052975327 @default.
• W2005048971 hasAuthorship W2005048971A5086202312 @default.
• W2005048971 hasBestOaLocation W20050489712 @default.
• W2005048971 hasConcept C126322002 @default.
• W2005048971 hasConcept C134018914 @default.
• W2005048971 hasConcept C151077648 @default.
• W2005048971 hasConcept C170493617 @default.
• W2005048971 hasConcept C185592680 @default.
• W2005048971 hasConcept C204232928 @default.
• W2005048971 hasConcept C2776885963 @default.
• W2005048971 hasConcept C2776907353 @default.
• W2005048971 hasConcept C2778140631 @default.
• W2005048971 hasConcept C2778750930 @default.
• W2005048971 hasConcept C2778815084 @default.
• W2005048971 hasConcept C2778938600 @default.
• W2005048971 hasConcept C2779248205 @default.
• W2005048971 hasConcept C2781063702 @default.
• W2005048971 hasConcept C2781181269 @default.
• W2005048971 hasConcept C3017995582 @default.
• W2005048971 hasConcept C71924100 @default.
• W2005048971 hasConcept C88016717 @default.
• W2005048971 hasConcept C98274493 @default.
• W2005048971 hasConceptScore W2005048971C126322002 @default.
• W2005048971 hasConceptScore W2005048971C134018914 @default.
• W2005048971 hasConceptScore W2005048971C151077648 @default.
• W2005048971 hasConceptScore W2005048971C170493617 @default.
• W2005048971 hasConceptScore W2005048971C185592680 @default.
• W2005048971 hasConceptScore W2005048971C204232928 @default.
• W2005048971 hasConceptScore W2005048971C2776885963 @default.
• W2005048971 hasConceptScore W2005048971C2776907353 @default.
• W2005048971 hasConceptScore W2005048971C2778140631 @default.
• W2005048971 hasConceptScore W2005048971C2778750930 @default.
• W2005048971 hasConceptScore W2005048971C2778815084 @default.
• W2005048971 hasConceptScore W2005048971C2778938600 @default.
• W2005048971 hasConceptScore W2005048971C2779248205 @default.
• W2005048971 hasConceptScore W2005048971C2781063702 @default.
• W2005048971 hasConceptScore W2005048971C2781181269 @default.
• W2005048971 hasConceptScore W2005048971C3017995582 @default.
• W2005048971 hasConceptScore W2005048971C71924100 @default.
• W2005048971 hasConceptScore W2005048971C88016717 @default.
• W2005048971 hasConceptScore W2005048971C98274493 @default.
• W2005048971 hasIssue "4" @default.
• W2005048971 hasLocation W20050489711 @default.
• W2005048971 hasLocation W20050489712 @default.
• W2005048971 hasLocation W20050489713 @default.
• W2005048971 hasOpenAccess W2005048971 @default.
• W2005048971 hasPrimaryLocation W20050489711 @default.
• W2005048971 hasRelatedWork W1972292508 @default.
• W2005048971 hasRelatedWork W1978057833 @default.
• W2005048971 hasRelatedWork W1980863532 @default.
• W2005048971 hasRelatedWork W1980969598 @default.
• W2005048971 hasRelatedWork W1989352034 @default.
• W2005048971 hasRelatedWork W2011433107 @default.
• W2005048971 hasRelatedWork W2040003803 @default.

• next