Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005049462> ?p ?o ?g. }
- W2005049462 endingPage "534" @default.
- W2005049462 startingPage "528" @default.
- W2005049462 abstract "The majority of the most effective monoclonal antibodies (mAbs) currently in the clinics bind to cancer or immune cells. Classic mechanisms of cell killing by therapeutic mAbs include antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity and induction of apoptosis by engagement of specific cell ligands. A few reports have described mAbs whose cytotoxic activity is Fc-independent and that do not induce the morphological and biochemical changes associated with the apoptosis-type of cell death. Even fewer works describe mAbs able to directly induce membrane lesions. Here, we discuss the available data on those molecules and their cell killing activity, with particular attention to the case of a mAb specific for the tumor-associated N-glycolyl (Neu5Gc)-GM3 ganglioside (GM3(Neu5Gc)). Some similarities are found in the cell death pathways triggered by these mAbs, but data are not abundant. We conclude that the usefulness of mAbs with a direct cytotoxic activity for immunotherapeutic strategies deserves deeper research." @default.
- W2005049462 created "2016-06-24" @default.
- W2005049462 creator A5024912561 @default.
- W2005049462 creator A5041741755 @default.
- W2005049462 date "2011-11-01" @default.
- W2005049462 modified "2023-10-14" @default.
- W2005049462 title "Lonely killers" @default.
- W2005049462 cites W1140848557 @default.
- W2005049462 cites W1560316276 @default.
- W2005049462 cites W1600186066 @default.
- W2005049462 cites W1782545213 @default.
- W2005049462 cites W1823397522 @default.
- W2005049462 cites W1930259341 @default.
- W2005049462 cites W1947496848 @default.
- W2005049462 cites W1963503658 @default.
- W2005049462 cites W1963633622 @default.
- W2005049462 cites W1964983191 @default.
- W2005049462 cites W1965205681 @default.
- W2005049462 cites W1970398250 @default.
- W2005049462 cites W1971242419 @default.
- W2005049462 cites W1976881265 @default.
- W2005049462 cites W1978047433 @default.
- W2005049462 cites W1980400322 @default.
- W2005049462 cites W1981012330 @default.
- W2005049462 cites W1981636006 @default.
- W2005049462 cites W1982090512 @default.
- W2005049462 cites W1983483937 @default.
- W2005049462 cites W1985987145 @default.
- W2005049462 cites W1987720155 @default.
- W2005049462 cites W1993155762 @default.
- W2005049462 cites W1993265987 @default.
- W2005049462 cites W1997275703 @default.
- W2005049462 cites W1997791763 @default.
- W2005049462 cites W1998205409 @default.
- W2005049462 cites W2001281410 @default.
- W2005049462 cites W2002865239 @default.
- W2005049462 cites W2003290529 @default.
- W2005049462 cites W2005252392 @default.
- W2005049462 cites W2010768484 @default.
- W2005049462 cites W2017142348 @default.
- W2005049462 cites W2026187161 @default.
- W2005049462 cites W2028852086 @default.
- W2005049462 cites W2031915840 @default.
- W2005049462 cites W2032231392 @default.
- W2005049462 cites W2032636887 @default.
- W2005049462 cites W2033195789 @default.
- W2005049462 cites W2034915619 @default.
- W2005049462 cites W2035446451 @default.
- W2005049462 cites W2042689793 @default.
- W2005049462 cites W2043946207 @default.
- W2005049462 cites W2044087137 @default.
- W2005049462 cites W2047219888 @default.
- W2005049462 cites W2049856484 @default.
- W2005049462 cites W2050091551 @default.
- W2005049462 cites W2053088103 @default.
- W2005049462 cites W2054873994 @default.
- W2005049462 cites W2055132644 @default.
- W2005049462 cites W2056061415 @default.
- W2005049462 cites W2056423039 @default.
- W2005049462 cites W2060471446 @default.
- W2005049462 cites W2064548992 @default.
- W2005049462 cites W2067844377 @default.
- W2005049462 cites W2073541926 @default.
- W2005049462 cites W2075021856 @default.
- W2005049462 cites W2077294419 @default.
- W2005049462 cites W2077630353 @default.
- W2005049462 cites W2083478820 @default.
- W2005049462 cites W2088159366 @default.
- W2005049462 cites W2090874281 @default.
- W2005049462 cites W2091229935 @default.
- W2005049462 cites W2093425230 @default.
- W2005049462 cites W2096319621 @default.
- W2005049462 cites W2099618978 @default.
- W2005049462 cites W2102895446 @default.
- W2005049462 cites W2108285674 @default.
- W2005049462 cites W2111913722 @default.
- W2005049462 cites W2112887207 @default.
- W2005049462 cites W2113104856 @default.
- W2005049462 cites W2115131874 @default.
- W2005049462 cites W2116060868 @default.
- W2005049462 cites W2117692326 @default.
- W2005049462 cites W2118180815 @default.
- W2005049462 cites W2123469465 @default.
- W2005049462 cites W2129268236 @default.
- W2005049462 cites W2132361489 @default.
- W2005049462 cites W2133205391 @default.
- W2005049462 cites W2144107170 @default.
- W2005049462 cites W2146602833 @default.
- W2005049462 cites W2150637218 @default.
- W2005049462 cites W2154913159 @default.
- W2005049462 cites W2158992634 @default.
- W2005049462 cites W2164374194 @default.
- W2005049462 cites W4241938147 @default.
- W2005049462 cites W4246687365 @default.
- W2005049462 cites W2003877881 @default.
- W2005049462 doi "https://doi.org/10.4161/mabs.3.6.17770" @default.
- W2005049462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3242839" @default.
- W2005049462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22123064" @default.