FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005053822> ?p ?o ?g. }

• W2005053822 endingPage "476" @default.
• W2005053822 startingPage "470" @default.
• W2005053822 abstract "Objective To investigate the correlation of cystic fibrosis transmembrane conductance regulator (CFTR) to cervical cancer progression and prognosis by examining CFTR expression levels in different cervical tissues and cell lines. Methods Paraffin-embedded cervical tissue samples (n=192) were collected for immunohistochemistry (IHC), while fresh cervical tissue samples (n=165) and human cervical cell lines were collected for protein and mRNA detection by quantitative real-time PCR and western blot, respectively. Correlations between CFTR expression levels to cancer clinicopathologic features and prognosis were statistically analyzed. Results Both CFTR mRNA and protein expression gradually increased from normal to precancerous (LSIL, HSIL) and cervical cancer tissues (p<0.05). Furthermore, CFTR expression level was well-correlated to tumor stage (p<0.001), histological grades (p<0.001), lymphatic metastasis (p<0.001), vascular invasion (p<0.05), interstitial invasive depth (p<0.05), tumor size (p<0.05) and HPV infection (p<0.05). In vitro, CFTR mRNA and protein were expressed strongly both in SiHa and HeLa, but little was seen in Caski and H8 (p<0.05). More importantly, overexpression of CFTR conferred significantly poorer survival in cervical carcinoma (Log rank p=0.028), although it was not an independent predictor for prognosis according to multivariate analysis (p>0.05). Conclusions These results suggest that higher CFTR expression is closely associated with cervical cancer progression, aggressive behaviors and poorer prognosis, indicating that CFTR may function as a novel tumor marker, a prospective prognostic indicator and a potential therapeutic target for cervical cancer." @default.
• W2005053822 created "2016-06-24" @default.
• W2005053822 creator A5000982380 @default.
• W2005053822 creator A5002188704 @default.
• W2005053822 creator A5012364593 @default.
• W2005053822 creator A5037123881 @default.
• W2005053822 creator A5037740266 @default.
• W2005053822 creator A5038510476 @default.
• W2005053822 creator A5047043019 @default.
• W2005053822 creator A5053170113 @default.
• W2005053822 date "2012-05-01" @default.
• W2005053822 modified "2023-10-01" @default.
• W2005053822 title "Overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) is associated with human cervical cancer malignancy, progression and prognosis" @default.
• W2005053822 cites W1533021978 @default.
• W2005053822 cites W1701691777 @default.
• W2005053822 cites W1965218780 @default.
• W2005053822 cites W1966676297 @default.
• W2005053822 cites W1973895561 @default.
• W2005053822 cites W1986374127 @default.
• W2005053822 cites W1992999268 @default.
• W2005053822 cites W2039589874 @default.
• W2005053822 cites W2044594872 @default.
• W2005053822 cites W2063565576 @default.
• W2005053822 cites W2064853333 @default.
• W2005053822 cites W2066235646 @default.
• W2005053822 cites W2069249077 @default.
• W2005053822 cites W2071809613 @default.
• W2005053822 cites W2079231943 @default.
• W2005053822 cites W2080385544 @default.
• W2005053822 cites W2086380492 @default.
• W2005053822 cites W2094727038 @default.
• W2005053822 cites W2095371103 @default.
• W2005053822 cites W2096110473 @default.
• W2005053822 cites W2098849055 @default.
• W2005053822 cites W2102777652 @default.
• W2005053822 cites W2106787323 @default.
• W2005053822 cites W2107277218 @default.
• W2005053822 cites W2110551282 @default.
• W2005053822 cites W2111951237 @default.
• W2005053822 cites W2121493145 @default.
• W2005053822 cites W2127418093 @default.
• W2005053822 cites W2144005516 @default.
• W2005053822 cites W2169451213 @default.
• W2005053822 cites W2314663284 @default.
• W2005053822 cites W3149555810 @default.
• W2005053822 doi "https://doi.org/10.1016/j.ygyno.2012.02.015" @default.
• W2005053822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22366595" @default.
• W2005053822 hasPublicationYear "2012" @default.
• W2005053822 type Work @default.
• W2005053822 sameAs 2005053822 @default.
• W2005053822 citedByCount "40" @default.
• W2005053822 countsByYear W20050538222013 @default.
• W2005053822 countsByYear W20050538222014 @default.
• W2005053822 countsByYear W20050538222015 @default.
• W2005053822 countsByYear W20050538222016 @default.
• W2005053822 countsByYear W20050538222017 @default.
• W2005053822 countsByYear W20050538222018 @default.
• W2005053822 countsByYear W20050538222019 @default.
• W2005053822 countsByYear W20050538222020 @default.
• W2005053822 countsByYear W20050538222021 @default.
• W2005053822 countsByYear W20050538222022 @default.
• W2005053822 countsByYear W20050538222023 @default.
• W2005053822 crossrefType "journal-article" @default.
• W2005053822 hasAuthorship W2005053822A5000982380 @default.
• W2005053822 hasAuthorship W2005053822A5002188704 @default.
• W2005053822 hasAuthorship W2005053822A5012364593 @default.
• W2005053822 hasAuthorship W2005053822A5037123881 @default.
• W2005053822 hasAuthorship W2005053822A5037740266 @default.
• W2005053822 hasAuthorship W2005053822A5038510476 @default.
• W2005053822 hasAuthorship W2005053822A5047043019 @default.
• W2005053822 hasAuthorship W2005053822A5053170113 @default.
• W2005053822 hasConcept C104317684 @default.
• W2005053822 hasConcept C121608353 @default.
• W2005053822 hasConcept C126322002 @default.
• W2005053822 hasConcept C142724271 @default.
• W2005053822 hasConcept C143998085 @default.
• W2005053822 hasConcept C204232928 @default.
• W2005053822 hasConcept C2776415932 @default.
• W2005053822 hasConcept C2776938444 @default.
• W2005053822 hasConcept C2778220009 @default.
• W2005053822 hasConcept C2778428886 @default.
• W2005053822 hasConcept C2779399171 @default.
• W2005053822 hasConcept C502942594 @default.
• W2005053822 hasConcept C55493867 @default.
• W2005053822 hasConcept C71924100 @default.
• W2005053822 hasConcept C86803240 @default.
• W2005053822 hasConceptScore W2005053822C104317684 @default.
• W2005053822 hasConceptScore W2005053822C121608353 @default.
• W2005053822 hasConceptScore W2005053822C126322002 @default.
• W2005053822 hasConceptScore W2005053822C142724271 @default.
• W2005053822 hasConceptScore W2005053822C143998085 @default.
• W2005053822 hasConceptScore W2005053822C204232928 @default.
• W2005053822 hasConceptScore W2005053822C2776415932 @default.
• W2005053822 hasConceptScore W2005053822C2776938444 @default.
• W2005053822 hasConceptScore W2005053822C2778220009 @default.
• W2005053822 hasConceptScore W2005053822C2778428886 @default.
• W2005053822 hasConceptScore W2005053822C2779399171 @default.
• W2005053822 hasConceptScore W2005053822C502942594 @default.

• next