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- W2005055732 abstract "The antagonistic properties of YM471, a potent nonpeptide vasopressin (AVP) V1A and V2 receptor antagonist, were characterized using human coronary artery smooth muscle cells (CASMC). YM471 potently inhibited specific binding of 3H-AVP to V1A receptors on human CASMC, exhibiting a Ki value of 0.49 nM. Furthermore, YM471 inhibited the AVP-induced increase in intracellular free Ca2+ concentration with an IC50 value of 1.42 nM, but exerted no agonistic activity on CASMC. Additionally, while AVP concentration-dependently induced hyperplasia and hypertrophy in CASMC, YM471 prevented these AVP-induced growth effects, exhibiting IC50 values of 0.93 and 2.64 nM, respectively. These results indicate that YM471 has high affinity for V1A receptors on, and high potency in inhibiting AVP-induced physiologic responses of, human CASMC." @default.
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- W2005055732 date "2002-10-01" @default.
- W2005055732 modified "2023-10-14" @default.
- W2005055732 title "Effect of YM471, a nonpeptide AVP receptor antagonist, on human coronary artery smooth muscle cells" @default.
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- W2005055732 doi "https://doi.org/10.1016/s0196-9781(02)00138-9" @default.
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