FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005057264> ?p ?o ?g. }

• W2005057264 endingPage "1128" @default.
• W2005057264 startingPage "1119" @default.
• W2005057264 abstract "Evolutionary rates provide important information about the pattern and mechanism of evolution. Although the rate of gene sequence evolution has been well studied, the rate of gene expression evolution is poorly understood. In particular, it is unclear whether the gene expression level and tissue specificity influence the divergence of expression profiles between orthologous genes. Here we address this question using a microarray data set comprising the expression signals of 10,607 pairs of orthologous human and mouse genes from over 60 tissues per species. We show that the level of gene expression and the degree of tissue specificity are generally conserved between the human and mouse orthologs. The rate of gene expression profile change during evolution is negatively correlated with the level of gene expression, measured by either the average or the highest level among all tissues examined. This is analogous to the observation that the rate of gene (or protein) sequence evolution is negatively correlated with the gene expression level. The impacts of the degree of tissue specificity on the evolutionary rate of gene sequence and that of expression profile, however, are opposite. Highly tissue-specific genes tend to evolve rapidly at the gene sequence level but slowly at the expression profile level. Thus, different forces and selective constraints must underlie the evolution of gene sequence and that of gene expression." @default.
• W2005057264 created "2016-06-24" @default.
• W2005057264 creator A5043019551 @default.
• W2005057264 creator A5082143549 @default.
• W2005057264 date "2006-03-06" @default.
• W2005057264 modified "2023-10-12" @default.
• W2005057264 title "Low Rates of Expression Profile Divergence in Highly Expressed Genes and Tissue-Specific Genes During Mammalian Evolution" @default.
• W2005057264 cites W1851269111 @default.
• W2005057264 cites W1965403600 @default.
• W2005057264 cites W1971977350 @default.
• W2005057264 cites W1973614663 @default.
• W2005057264 cites W1999027354 @default.
• W2005057264 cites W2012840807 @default.
• W2005057264 cites W2014279841 @default.
• W2005057264 cites W2018601871 @default.
• W2005057264 cites W2022756254 @default.
• W2005057264 cites W2027762334 @default.
• W2005057264 cites W2037594820 @default.
• W2005057264 cites W2042312893 @default.
• W2005057264 cites W2063593640 @default.
• W2005057264 cites W2065172786 @default.
• W2005057264 cites W2069420439 @default.
• W2005057264 cites W2088014737 @default.
• W2005057264 cites W2095178364 @default.
• W2005057264 cites W2095321122 @default.
• W2005057264 cites W2103320667 @default.
• W2005057264 cites W2104099887 @default.
• W2005057264 cites W2109258478 @default.
• W2005057264 cites W2111696544 @default.
• W2005057264 cites W2113275510 @default.
• W2005057264 cites W2115148114 @default.
• W2005057264 cites W2119632499 @default.
• W2005057264 cites W2123384627 @default.
• W2005057264 cites W2125204768 @default.
• W2005057264 cites W2128969076 @default.
• W2005057264 cites W2130353827 @default.
• W2005057264 cites W2130871092 @default.
• W2005057264 cites W2130925862 @default.
• W2005057264 cites W2131160279 @default.
• W2005057264 cites W2135160221 @default.
• W2005057264 cites W2136749660 @default.
• W2005057264 cites W2142055410 @default.
• W2005057264 cites W2144910983 @default.
• W2005057264 cites W2146453000 @default.
• W2005057264 cites W2146849272 @default.
• W2005057264 cites W2156340505 @default.
• W2005057264 cites W2159049360 @default.
• W2005057264 cites W2162871532 @default.
• W2005057264 cites W2163963584 @default.
• W2005057264 cites W2164242630 @default.
• W2005057264 cites W2164683872 @default.
• W2005057264 cites W2165366028 @default.
• W2005057264 cites W2165810656 @default.
• W2005057264 cites W2170989872 @default.
• W2005057264 cites W4236341438 @default.
• W2005057264 cites W4362204953 @default.
• W2005057264 doi "https://doi.org/10.1093/molbev/msj119" @default.
• W2005057264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16520335" @default.
• W2005057264 hasPublicationYear "2006" @default.
• W2005057264 type Work @default.
• W2005057264 sameAs 2005057264 @default.
• W2005057264 citedByCount "135" @default.
• W2005057264 countsByYear W20050572642012 @default.
• W2005057264 countsByYear W20050572642013 @default.
• W2005057264 countsByYear W20050572642014 @default.
• W2005057264 countsByYear W20050572642015 @default.
• W2005057264 countsByYear W20050572642016 @default.
• W2005057264 countsByYear W20050572642017 @default.
• W2005057264 countsByYear W20050572642018 @default.
• W2005057264 countsByYear W20050572642019 @default.
• W2005057264 countsByYear W20050572642020 @default.
• W2005057264 countsByYear W20050572642021 @default.
• W2005057264 countsByYear W20050572642022 @default.
• W2005057264 countsByYear W20050572642023 @default.
• W2005057264 crossrefType "journal-article" @default.
• W2005057264 hasAuthorship W2005057264A5043019551 @default.
• W2005057264 hasAuthorship W2005057264A5082143549 @default.
• W2005057264 hasConcept C104317684 @default.
• W2005057264 hasConcept C138885662 @default.
• W2005057264 hasConcept C150194340 @default.
• W2005057264 hasConcept C165864922 @default.
• W2005057264 hasConcept C166393388 @default.
• W2005057264 hasConcept C207390915 @default.
• W2005057264 hasConcept C2777949028 @default.
• W2005057264 hasConcept C2778112365 @default.
• W2005057264 hasConcept C41895202 @default.
• W2005057264 hasConcept C54355233 @default.
• W2005057264 hasConcept C86803240 @default.
• W2005057264 hasConcept C90132467 @default.
• W2005057264 hasConceptScore W2005057264C104317684 @default.
• W2005057264 hasConceptScore W2005057264C138885662 @default.
• W2005057264 hasConceptScore W2005057264C150194340 @default.
• W2005057264 hasConceptScore W2005057264C165864922 @default.
• W2005057264 hasConceptScore W2005057264C166393388 @default.
• W2005057264 hasConceptScore W2005057264C207390915 @default.
• W2005057264 hasConceptScore W2005057264C2777949028 @default.
• W2005057264 hasConceptScore W2005057264C2778112365 @default.
• W2005057264 hasConceptScore W2005057264C41895202 @default.

• next