FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005059957> ?p ?o ?g. }

• W2005059957 endingPage "1687" @default.
• W2005059957 startingPage "1678" @default.
• W2005059957 abstract "Norcantharidin (NCTD) is known to have anti-cancer potentials. The aim of this study was to assess the apoptosis-inducing effect of NCTD on human leukemic Jurkat cells. We found that NCTD preferentially inhibited the growth of Jurkat cells in a dose- and time-dependent manner, but not the growth of normal blood mononuclear cells (MNC). Pretreatment with agonistic (CH-11) and antagonistic (ZB4) Fas antibodies on Jurkat cells showed that NCTD-induced apoptosis might not involve Fas–FasL signaling. Flow cytometric assay of Jurkat cells treated with NCTD showed a markedly increased sub-G1 DNA phase and cell cycle arrest at S phase. Western blot analysis of NCTD-treated cells showed increased expressions of cytochrome c, active caspase-9 and -3, and cleavage of poly(ADP–ribose) polymerase (PARP), but the expressions of Bcl-2, Bax and apoptosis-inducing factor were not increased. The transcription factor STAT1 was translocated from cytosol to nucleus. Pancaspase inhibitor z-VAD-FMK not only limited the level of sub-G1 phase, but also prevented the degradation of PARP in NCTD-treated cells. The NCTD-induced cell cycle arrest and apoptosis were mediated through the regulation of ataxia-telangiectasia mutated (ATM), rather than P63 protein. The conditioned medium produced from human MNC (NCTD–MNC-CM) increased the percentage of apoptotic cells and the expression of PARP cleavage in Jurkat cells. Protein array assay of NCTD–MNC-CM showed 32.4- and 6.2-folds increases in TNF-α and GM–CSF, respectively, and the expression of MCP-1, GRO, RANTES and IL-10 was decreased. We conclude that NCTD can induce apoptosis in human leukemic Jurkat cells via a caspase-dependent pathway without affecting the viability of normal MNC, and that the apoptosis-inducing effect of NCTD can also be achieved by soluble cytokines produced from peripheral MNC." @default.
• W2005059957 created "2016-06-24" @default.
• W2005059957 creator A5008011152 @default.
• W2005059957 creator A5011493063 @default.
• W2005059957 creator A5015836216 @default.
• W2005059957 creator A5064655192 @default.
• W2005059957 creator A5067175625 @default.
• W2005059957 date "2007-09-01" @default.
• W2005059957 modified "2023-10-16" @default.
• W2005059957 title "Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells" @default.
• W2005059957 cites W1595815978 @default.
• W2005059957 cites W1975278125 @default.
• W2005059957 cites W1989862901 @default.
• W2005059957 cites W1990189820 @default.
• W2005059957 cites W1995022664 @default.
• W2005059957 cites W2005177899 @default.
• W2005059957 cites W2005394134 @default.
• W2005059957 cites W2011767881 @default.
• W2005059957 cites W2016785848 @default.
• W2005059957 cites W2020428280 @default.
• W2005059957 cites W2027880353 @default.
• W2005059957 cites W2036718506 @default.
• W2005059957 cites W2063377766 @default.
• W2005059957 cites W2064572112 @default.
• W2005059957 cites W2078172545 @default.
• W2005059957 cites W2088040592 @default.
• W2005059957 cites W2089223655 @default.
• W2005059957 cites W2094275092 @default.
• W2005059957 cites W2095881985 @default.
• W2005059957 cites W2108165481 @default.
• W2005059957 cites W2119828989 @default.
• W2005059957 cites W2126155653 @default.
• W2005059957 cites W2128151803 @default.
• W2005059957 cites W2134078431 @default.
• W2005059957 cites W2148810250 @default.
• W2005059957 cites W2149966409 @default.
• W2005059957 cites W2149967205 @default.
• W2005059957 cites W2164320307 @default.
• W2005059957 cites W2170712027 @default.
• W2005059957 cites W2173560213 @default.
• W2005059957 cites W4234623614 @default.
• W2005059957 doi "https://doi.org/10.1016/j.fct.2007.03.003" @default.
• W2005059957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17442474" @default.
• W2005059957 hasPublicationYear "2007" @default.
• W2005059957 type Work @default.
• W2005059957 sameAs 2005059957 @default.
• W2005059957 citedByCount "48" @default.
• W2005059957 countsByYear W20050599572012 @default.
• W2005059957 countsByYear W20050599572013 @default.
• W2005059957 countsByYear W20050599572014 @default.
• W2005059957 countsByYear W20050599572015 @default.
• W2005059957 countsByYear W20050599572016 @default.
• W2005059957 countsByYear W20050599572017 @default.
• W2005059957 countsByYear W20050599572018 @default.
• W2005059957 countsByYear W20050599572019 @default.
• W2005059957 countsByYear W20050599572020 @default.
• W2005059957 countsByYear W20050599572021 @default.
• W2005059957 countsByYear W20050599572022 @default.
• W2005059957 countsByYear W20050599572023 @default.
• W2005059957 crossrefType "journal-article" @default.
• W2005059957 hasAuthorship W2005059957A5008011152 @default.
• W2005059957 hasAuthorship W2005059957A5011493063 @default.
• W2005059957 hasAuthorship W2005059957A5015836216 @default.
• W2005059957 hasAuthorship W2005059957A5064655192 @default.
• W2005059957 hasAuthorship W2005059957A5067175625 @default.
• W2005059957 hasConcept C153911025 @default.
• W2005059957 hasConcept C179464577 @default.
• W2005059957 hasConcept C182979987 @default.
• W2005059957 hasConcept C185592680 @default.
• W2005059957 hasConcept C190283241 @default.
• W2005059957 hasConcept C203014093 @default.
• W2005059957 hasConcept C2776090121 @default.
• W2005059957 hasConcept C29537977 @default.
• W2005059957 hasConcept C31573885 @default.
• W2005059957 hasConcept C53227056 @default.
• W2005059957 hasConcept C552990157 @default.
• W2005059957 hasConcept C55493867 @default.
• W2005059957 hasConcept C66008609 @default.
• W2005059957 hasConcept C82381507 @default.
• W2005059957 hasConcept C86803240 @default.
• W2005059957 hasConcept C8891405 @default.
• W2005059957 hasConcept C95444343 @default.
• W2005059957 hasConceptScore W2005059957C153911025 @default.
• W2005059957 hasConceptScore W2005059957C179464577 @default.
• W2005059957 hasConceptScore W2005059957C182979987 @default.
• W2005059957 hasConceptScore W2005059957C185592680 @default.
• W2005059957 hasConceptScore W2005059957C190283241 @default.
• W2005059957 hasConceptScore W2005059957C203014093 @default.
• W2005059957 hasConceptScore W2005059957C2776090121 @default.
• W2005059957 hasConceptScore W2005059957C29537977 @default.
• W2005059957 hasConceptScore W2005059957C31573885 @default.
• W2005059957 hasConceptScore W2005059957C53227056 @default.
• W2005059957 hasConceptScore W2005059957C552990157 @default.
• W2005059957 hasConceptScore W2005059957C55493867 @default.
• W2005059957 hasConceptScore W2005059957C66008609 @default.
• W2005059957 hasConceptScore W2005059957C82381507 @default.
• W2005059957 hasConceptScore W2005059957C86803240 @default.
• W2005059957 hasConceptScore W2005059957C8891405 @default.

• next