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• W2005060410 abstract "The clinical and pathologic features of a rare case o f follicular carcinoma with small foci o f poorly differentiated and anaplastic carcinoma are presented. Eight years after the removal o f the primary neoplasm, the patient developed pulmonary and brain metastases that were predominantly composed o f the poorly differentiated and anaplastic components. A comparative immunohistochemical and molecular analysis o f pS3 status in the follicular, poorly differentiated and anaplastic components o f the tumor was performed. pS3 immunostaining was restricted to the poorly differentiated and anaplastic areas. Single strand conformation polymorphism analysis (SSCP-PCR) from DNA obtained by microdissection demonstrated the presence o f a mutation (TAT→TGT; Tyr→Cys) in codon 220, exon six o f the pS3 gene in the anaplastic component, that was absent in the well-differentiated follicular areas. The results o f that study in this rare tumor support that pS3 has a tumor progression role in thyroid tumorigenesis." @default.
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• W2005060410 date "1996-01-01" @default.
• W2005060410 modified "2023-10-15" @default.
• W2005060410 title "p53 in a Thyroid Follicular Carcinoma with Foci of Poorly Differentiated and Anaplastic Carcinoma" @default.
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• W2005060410 doi "https://doi.org/10.1016/s0344-0338(96)80159-2" @default.
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