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• W2005060891 endingPage "103" @default.
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• W2005060891 abstract "Abstract The effect of agents stimulating the oxidative burst (OB) in oil-elicited guinea pig peritoneal macrophages (MPs) on cyclic adenosine 3′,5′-monophosphate (cAMP) levels was examined. We found that: (i) Phorbol myristate acetate (PMA), the Ca2+ ionophore A23187, concanavalin A (Con A), wheat germ agglutinin (WGA), N-formyl- l -methionyl- l -leucyl- l -phenylalanine (FMLP) and opsonized zymosan, elevated cAMP levels two- to fivefold; (ii) the biologically inactive PMA analog, 4-O-methyl-PMA, was proportionally less effective than PMA in stimulating cAMP accumulation; (iii) increased levels of cAMP were evident after 10 min of incubation with the stimulants, in the presence of the phosphodiesterase inhibitor 3-isobutyl methylxanthine (IBX); (iv) basal cAMP levels in MPs increased proportionally with the extracellular Ca2+ concentration; (v) the cAMP-elevating effect of all stimulants (with the exception of A23187) was more pronounced in low Ca2+ media, associated with lower basal cAMP levels. A23187 did not elevate cAMP levels in the absence of extracellular Ca2+; (vi) short-term incubation of MPs with arachidonic acid and with the arachidonic acid precursor, linoleic acid, induced an increase in the level of cAMP; (vii) the elevations in cAMP levels induced by OB stimulants were enhanced, not blocked, by mepacrine, 5,8,11,14-eicosatetraynoic acid (ETYA), indomethacin or aspirin, demonstrating that prostaglandin (PG) synthesis was not involved; (viii) the cAMP-elevating effect of arachidonic and linoleic acids was blocked by ETYA and indomethacin, indicating that it was mediated by PGs. The mechanism by which OB stimulants elevate cAMP levels could not be determined but changes in the cellular level of Ca2+ seem to play a pivotal role." @default.
• W2005060891 created "2016-06-24" @default.
• W2005060891 creator A5046513816 @default.
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• W2005060891 date "1981-06-01" @default.
• W2005060891 modified "2023-09-25" @default.
• W2005060891 title "Activation of macrophage adenylate cyclase by stimulants of the oxidative burst and by arachidonic acid—Two distinct mechanisms" @default.
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• W2005060891 doi "https://doi.org/10.1016/0008-8749(81)90356-7" @default.
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