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• W2005062862 abstract "In Brief Study Design. Prospective evaluation of apolipoprotein E (APOE) genotypes in 106 consecutive patients with stenosis of the cervical spinal canal. Objective. To determine the association between cervical spondylotic myelopathy (CSM) in patients with chronic spinal cord compression and the APOE genotype. Summary of Background Data. The APOE allele ε4 is a risk factor for the occurrence, progression, and poor outcome in several neurologic diseases. Information of the association between APOE genotype and CSM in the literature are lacking so far. Methods. One hundred six consecutive patients with chronic cervical spinal cord compression due to stenosis of the spinal canal were evaluated prospectively. APOE genotypes were determined by polymerase chain reaction followed by restriction enzyme digestion and sodiumdodecylsulfate poyacrylamide gel electrophoresis (SDS PAGE) of digested fragments. Clinical and radiologic variables evaluated were age, occurrence of CSM, duration of symptoms, number of affected segments, and diameter of spinal canal of most affected segment. Univariate association between variables was tested. A backward stepwise method was used to construct multivariate logistic regression models in relation to the occurrence of CSM as dependent variable. Results. The following distribution of APOE genotypes was found: ε2ε2 3 patients (2.8%), ε2ε3 9 patients (8.5%), ε2ε4 1 patient (0.9), ε3ε3 67 patients (63.2%), ε3ε4 24 patients (22.6%), ε4ε4 2 patients (1.9%). Univariate analysis showed that patients with chronic spinal cord compression and homo- or heterozygous allele ε4 are more likely to develop CSM than patients without allele ε4 (65.0% vs. 35.0%, P < 0008; OR 3.5; 95% CI 1.3–9.8). This effect remained significant in a binary logistic regression model adjusted to other known risk factors for CSM. Inclusion of the variable homo- or heterozygous ε4 allele led to an increased goodness of fit of the model compared with the model without ε4. Conclusion. This study supports the hypothesis that the APOE ε4 allele increases the risk of CSM in patients with chronic cervical spinal cord compression; however, a larger prospective population-based study is needed to answer this question definitively. APOE genotype was determined in patients with stenosis of the cervical spinal canal by polymerase chain reaction followed by restriction enzyme digestion and SDS PAGE of digested fragments. Patients with a homo- or heterozygous ε4 were more likely to develop CSM than patients without allele ε4." @default.
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• W2005062862 date "2008-03-01" @default.
• W2005062862 modified "2023-10-18" @default.
• W2005062862 title "Apolipoprotein E Gene Polymorphism and the Risk of Cervical Myelopathy in Patients With Chronic Spinal Cord Compression" @default.
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• W2005062862 doi "https://doi.org/10.1097/brs.0b013e3181657cf7" @default.
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