FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005064710> ?p ?o ?g. }

• W2005064710 endingPage "1004" @default.
• W2005064710 startingPage "998" @default.
• W2005064710 abstract "The Chinese medicinal formula Guanxin Shutong capsule (GXSTC) has been used for almost 10 years as a clinical treatment for chest pain, depression, palpitation and cardiovascular diseases. The aim of this study was to investigate the effects of GXSTC drug‑containing serum on tumor necrosis factor‑α (TNF‑α)‑stimulated endothelial cells. Cell viability was measured by MTT assay, and nitric oxide (NO) levels and NO synthase (NOS) activity were measured as standards of endothelial dysfunction. Malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity were evaluated using commercial kits. In addition, the protein expression of endothelial NOS (eNOS), AKT and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits was examined to evaluate the effect of GXSTC drug‑containing serum on ECV304 cells. GXSTC significantly reversed the decrease in NO production induced by TNF‑α (5 ng/ml) in ECV304 cells. The expression of NADPH oxidase subunits was increased by TNF‑α treatment, but markedly inhibited by treatment with GXSTC in TNF‑α‑stimulated cells. In summary, GXSTC increased the production of NO in ECV304 cells and exerted a protective effect on ECV304 cells stimulated with TNF‑α by upregulating the mRNA and protein expression of eNOS. This was accompanied by increased SOD activity and reduced MDA levels. These results suggested that GXSTC protects the endothelium via the NO pathway and exhibits antioxidant effects." @default.
• W2005064710 created "2016-06-24" @default.
• W2005064710 creator A5013734885 @default.
• W2005064710 creator A5023346134 @default.
• W2005064710 creator A5046852793 @default.
• W2005064710 creator A5060470951 @default.
• W2005064710 date "2014-06-20" @default.
• W2005064710 modified "2023-09-24" @default.
• W2005064710 title "Protective effects of Guanxin Shutong capsule drug-containing serum on tumor necrosis factor-α-induced endothelial dysfunction through nicotinamide adenine dinucleotide phosphate oxidase and the nitric oxide pathway" @default.
• W2005064710 cites W1966726553 @default.
• W2005064710 cites W1969149591 @default.
• W2005064710 cites W1979269047 @default.
• W2005064710 cites W1990484950 @default.
• W2005064710 cites W2020292131 @default.
• W2005064710 cites W2021264914 @default.
• W2005064710 cites W2023811276 @default.
• W2005064710 cites W2025806325 @default.
• W2005064710 cites W2053179924 @default.
• W2005064710 cites W2054151583 @default.
• W2005064710 cites W2079159302 @default.
• W2005064710 cites W2090282820 @default.
• W2005064710 cites W2100864427 @default.
• W2005064710 cites W2101180993 @default.
• W2005064710 cites W2123799914 @default.
• W2005064710 cites W2148637873 @default.
• W2005064710 cites W2162007164 @default.
• W2005064710 cites W2148806465 @default.
• W2005064710 doi "https://doi.org/10.3892/etm.2014.1795" @default.
• W2005064710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4113548" @default.
• W2005064710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25120637" @default.
• W2005064710 hasPublicationYear "2014" @default.
• W2005064710 type Work @default.
• W2005064710 sameAs 2005064710 @default.
• W2005064710 citedByCount "4" @default.
• W2005064710 countsByYear W20050647102017 @default.
• W2005064710 countsByYear W20050647102021 @default.
• W2005064710 countsByYear W20050647102022 @default.
• W2005064710 crossrefType "journal-article" @default.
• W2005064710 hasAuthorship W2005064710A5013734885 @default.
• W2005064710 hasAuthorship W2005064710A5023346134 @default.
• W2005064710 hasAuthorship W2005064710A5046852793 @default.
• W2005064710 hasAuthorship W2005064710A5060470951 @default.
• W2005064710 hasBestOaLocation W20050647101 @default.
• W2005064710 hasConcept C123012128 @default.
• W2005064710 hasConcept C134018914 @default.
• W2005064710 hasConcept C17991360 @default.
• W2005064710 hasConcept C181199279 @default.
• W2005064710 hasConcept C185592680 @default.
• W2005064710 hasConcept C190283241 @default.
• W2005064710 hasConcept C202751555 @default.
• W2005064710 hasConcept C2775838275 @default.
• W2005064710 hasConcept C2776151105 @default.
• W2005064710 hasConcept C2776992346 @default.
• W2005064710 hasConcept C2777622882 @default.
• W2005064710 hasConcept C2777989768 @default.
• W2005064710 hasConcept C2778326061 @default.
• W2005064710 hasConcept C2778401633 @default.
• W2005064710 hasConcept C2779719074 @default.
• W2005064710 hasConcept C2779728014 @default.
• W2005064710 hasConcept C38485361 @default.
• W2005064710 hasConcept C519581460 @default.
• W2005064710 hasConcept C53227056 @default.
• W2005064710 hasConcept C55493867 @default.
• W2005064710 hasConcept C86803240 @default.
• W2005064710 hasConcept C98274493 @default.
• W2005064710 hasConceptScore W2005064710C123012128 @default.
• W2005064710 hasConceptScore W2005064710C134018914 @default.
• W2005064710 hasConceptScore W2005064710C17991360 @default.
• W2005064710 hasConceptScore W2005064710C181199279 @default.
• W2005064710 hasConceptScore W2005064710C185592680 @default.
• W2005064710 hasConceptScore W2005064710C190283241 @default.
• W2005064710 hasConceptScore W2005064710C202751555 @default.
• W2005064710 hasConceptScore W2005064710C2775838275 @default.
• W2005064710 hasConceptScore W2005064710C2776151105 @default.
• W2005064710 hasConceptScore W2005064710C2776992346 @default.
• W2005064710 hasConceptScore W2005064710C2777622882 @default.
• W2005064710 hasConceptScore W2005064710C2777989768 @default.
• W2005064710 hasConceptScore W2005064710C2778326061 @default.
• W2005064710 hasConceptScore W2005064710C2778401633 @default.
• W2005064710 hasConceptScore W2005064710C2779719074 @default.
• W2005064710 hasConceptScore W2005064710C2779728014 @default.
• W2005064710 hasConceptScore W2005064710C38485361 @default.
• W2005064710 hasConceptScore W2005064710C519581460 @default.
• W2005064710 hasConceptScore W2005064710C53227056 @default.
• W2005064710 hasConceptScore W2005064710C55493867 @default.
• W2005064710 hasConceptScore W2005064710C86803240 @default.
• W2005064710 hasConceptScore W2005064710C98274493 @default.
• W2005064710 hasIssue "3" @default.
• W2005064710 hasLocation W20050647101 @default.
• W2005064710 hasLocation W20050647102 @default.
• W2005064710 hasLocation W20050647103 @default.
• W2005064710 hasLocation W20050647104 @default.
• W2005064710 hasOpenAccess W2005064710 @default.
• W2005064710 hasPrimaryLocation W20050647101 @default.
• W2005064710 hasRelatedWork W2010056730 @default.
• W2005064710 hasRelatedWork W2021658296 @default.
• W2005064710 hasRelatedWork W2046632348 @default.
• W2005064710 hasRelatedWork W2095720502 @default.

• next