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- W2005065605 abstract "<h3>In Reply.—</h3> Hypercarbia decreases 2-deoxyglucose (2-DG) uptake in brain.<sup>1</sup>This reflects a true decrease in glucose utilization during hypercarbia, as there is both a decreased need for glucose since metabolic rate is depressed,<sup>2</sup>and there is an inhibition of glycolyses mediated by the effect of pH on phosphofructokinase.<sup>3</sup>Uptake of 2-DG is mediated by the glucose carrier and is dependent on concentration but independent of blood flow. As used in our study, it would be independent of a breakdown in the blood brain barrier. The autoradiographic density reflects 2-DG that has been metabolized by hexokinase and trapped as 2-DG-6-phosphate. Forty-five minutes after an intravenous bolus injection, less than 10% would still remain in the precursor pool. The arterial plasma concentration of 2-DG decreases exponentially after a single injection, and even if this were freely diffusable with extracellular spaces it would not add detectably to the autoradiographic picture. Breakdown of" @default.
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- W2005065605 date "1977-01-01" @default.
- W2005065605 modified "2023-09-27" @default.
- W2005065605 title "Focal Motor Seizures-Reply" @default.
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- W2005065605 doi "https://doi.org/10.1001/archneur.1977.00500130077017" @default.
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