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• W2005067689 abstract "The capacity of purified γG1 and γG2 anti-sheep red blood cell (SRBC) antibodies to exert antigen-specific feedback regulations on the primary in vitro immune response to SRBC was studied. Antibodies were administered to the culture in the native form, as sheep erythrocyte-antibody complexes or as pepsin-derived F(ab′)2 antibody fragments. Marked differences in the feedback regulatory effects of γG1 and γG2 antibodies were found. Antibodies of the γG1 class suppressed the immune response to SRBC, whereas γG2 antibodies isolated from the same serum exerted an augmenting effect on antibody synthesis. These opposing feedback effects on in vitro antibody synthesis were immunologically specific, relatively insensitive to changes in antigen concentrations, and could be elicited by either adding antibodies and antigen separately to the culture or as preformed antigen-antibody complexes. Experiments comparing the activities of the F(ab′)2 antibody fragments with the parent γG1 and γG2 antibodies suggested that the Fc fragments may be involved in these regulatory effects on the immune response. It is concluded that the antigen-specific suppressive and augmenting effects on antibody synthesis shown here are determined by the antibody class. In addition, we suggest that these opposing antibody-mediated feedback effects may represent one of the important elements of the immune response." @default.
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• W2005067689 date "1975-02-01" @default.
• W2005067689 modified "2023-09-23" @default.
• W2005067689 title "Suppression and augmentation of the primary in vitro immune response by different classes of antibodies" @default.
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• W2005067689 doi "https://doi.org/10.1016/0008-8749(75)90017-9" @default.
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