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• W2005071431 endingPage "1208" @default.
• W2005071431 startingPage "1183" @default.
• W2005071431 abstract "Most new mutations are deleterious and are eventually eliminated by natural selection. But in an adapting population, the rapid amplification of beneficial mutations can hinder the removal of deleterious variants in nearby regions of the genome, altering the patterns of sequence evolution. Here, we analyze the interactions between beneficial driver mutations and linked deleterious passengers during the course of adaptation. We derive analytical expressions for the substitution rate of a deleterious mutation as a function of its fitness cost, as well as the reduction in the beneficial substitution rate due to the genetic load of the passengers. We find that the fate of each deleterious mutation varies dramatically with the rate and spectrum of beneficial mutations and the deleterious substitution rate depends nonmonotonically on the population size and the rate of adaptation. By quantifying this dependence, our results allow us to estimate which deleterious mutations will be likely to fix and how many of these mutations must arise before the progress of adaptation is significantly reduced." @default.
• W2005071431 created "2016-06-24" @default.
• W2005071431 creator A5051640845 @default.
• W2005071431 creator A5069948947 @default.
• W2005071431 date "2014-09-05" @default.
• W2005071431 modified "2023-10-02" @default.
• W2005071431 title "Deleterious Passengers in Adapting Populations" @default.
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• W2005071431 doi "https://doi.org/10.1534/genetics.114.170233" @default.
• W2005071431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4224160" @default.
• W2005071431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25194161" @default.
• W2005071431 hasPublicationYear "2014" @default.
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