FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005072332> ?p ?o ?g. }

• W2005072332 endingPage "53" @default.
• W2005072332 startingPage "44" @default.
• W2005072332 abstract "Survivin is a member of the inhibitor of apoptosis (IAP) family of negative regulators of programmed cell death that is frequently overexpressed in human tumors. Survivin is not only involved in the regulation of apoptosis, but is also known to play a role in the control of cell cycle progression at the G2/M phase. Survivin is a predominantly cytoplasmic protein expressed in a cell cycle-dependent manner, but the mechanism(s) that determine its nuclear-cytoplasmic localization have not been described. In this study, we report that Survivin is a nuclear shuttling protein that is actively exported from the nucleus via the CRM1-dependent pathway. Nuclear export of Survivin is independent of the export of other shuttling proteins that control the G2/M phase transition, such as cyclin B1 and cdc25. The carboxy-terminal domain of Survivin is both necessary and sufficient for its nuclear export, although this region does not contain a functional leucine-rich nuclear export signal. Differences in the amino acid sequence of this region determine the dramatically different localization of Survivin (in the cytoplasm) and its splicing variant Survivin-ΔEx3 (in the nucleus). The carboxy-terminal end of Survivin-ΔEx3 contains a bipartite nuclear localization signal, not present in Survivin, which mediates its strong nuclear accumulation. These data suggest that active transport between the nucleus and cytoplasm may constitute an important regulatory mechanism for Survivin function." @default.
• W2005072332 created "2016-06-24" @default.
• W2005072332 creator A5019935493 @default.
• W2005072332 creator A5022063365 @default.
• W2005072332 creator A5042275454 @default.
• W2005072332 creator A5057601657 @default.
• W2005072332 creator A5087199549 @default.
• W2005072332 date "2002-04-01" @default.
• W2005072332 modified "2023-10-05" @default.
• W2005072332 title "CRM1-Mediated Nuclear Export Determines the Cytoplasmic Localization of the Antiapoptotic Protein Survivin" @default.
• W2005072332 cites W1595083214 @default.
• W2005072332 cites W1662899239 @default.
• W2005072332 cites W1901442544 @default.
• W2005072332 cites W1963705823 @default.
• W2005072332 cites W1977558343 @default.
• W2005072332 cites W1979886704 @default.
• W2005072332 cites W1981006523 @default.
• W2005072332 cites W1984467395 @default.
• W2005072332 cites W1996313023 @default.
• W2005072332 cites W2008922773 @default.
• W2005072332 cites W2033722975 @default.
• W2005072332 cites W2035523654 @default.
• W2005072332 cites W2044568075 @default.
• W2005072332 cites W2060088582 @default.
• W2005072332 cites W2091459179 @default.
• W2005072332 cites W2100067355 @default.
• W2005072332 cites W2105016405 @default.
• W2005072332 cites W2119827462 @default.
• W2005072332 cites W2124785173 @default.
• W2005072332 cites W2145913988 @default.
• W2005072332 cites W2153988632 @default.
• W2005072332 cites W2154795389 @default.
• W2005072332 cites W2165306451 @default.
• W2005072332 cites W2167490100 @default.
• W2005072332 cites W2168696636 @default.
• W2005072332 doi "https://doi.org/10.1006/excr.2002.5492" @default.
• W2005072332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11925104" @default.
• W2005072332 hasPublicationYear "2002" @default.
• W2005072332 type Work @default.
• W2005072332 sameAs 2005072332 @default.
• W2005072332 citedByCount "144" @default.
• W2005072332 countsByYear W20050723322012 @default.
• W2005072332 countsByYear W20050723322013 @default.
• W2005072332 countsByYear W20050723322014 @default.
• W2005072332 countsByYear W20050723322015 @default.
• W2005072332 countsByYear W20050723322016 @default.
• W2005072332 countsByYear W20050723322017 @default.
• W2005072332 countsByYear W20050723322018 @default.
• W2005072332 countsByYear W20050723322019 @default.
• W2005072332 countsByYear W20050723322020 @default.
• W2005072332 countsByYear W20050723322021 @default.
• W2005072332 countsByYear W20050723322022 @default.
• W2005072332 countsByYear W20050723322023 @default.
• W2005072332 crossrefType "journal-article" @default.
• W2005072332 hasAuthorship W2005072332A5019935493 @default.
• W2005072332 hasAuthorship W2005072332A5022063365 @default.
• W2005072332 hasAuthorship W2005072332A5042275454 @default.
• W2005072332 hasAuthorship W2005072332A5057601657 @default.
• W2005072332 hasAuthorship W2005072332A5087199549 @default.
• W2005072332 hasConcept C104317684 @default.
• W2005072332 hasConcept C190062978 @default.
• W2005072332 hasConcept C190283241 @default.
• W2005072332 hasConcept C2775975398 @default.
• W2005072332 hasConcept C2777408456 @default.
• W2005072332 hasConcept C2780114586 @default.
• W2005072332 hasConcept C29512474 @default.
• W2005072332 hasConcept C29537977 @default.
• W2005072332 hasConcept C31573885 @default.
• W2005072332 hasConcept C49805395 @default.
• W2005072332 hasConcept C502942594 @default.
• W2005072332 hasConcept C54757728 @default.
• W2005072332 hasConcept C55493867 @default.
• W2005072332 hasConcept C59157529 @default.
• W2005072332 hasConcept C86339819 @default.
• W2005072332 hasConcept C86803240 @default.
• W2005072332 hasConcept C95444343 @default.
• W2005072332 hasConceptScore W2005072332C104317684 @default.
• W2005072332 hasConceptScore W2005072332C190062978 @default.
• W2005072332 hasConceptScore W2005072332C190283241 @default.
• W2005072332 hasConceptScore W2005072332C2775975398 @default.
• W2005072332 hasConceptScore W2005072332C2777408456 @default.
• W2005072332 hasConceptScore W2005072332C2780114586 @default.
• W2005072332 hasConceptScore W2005072332C29512474 @default.
• W2005072332 hasConceptScore W2005072332C29537977 @default.
• W2005072332 hasConceptScore W2005072332C31573885 @default.
• W2005072332 hasConceptScore W2005072332C49805395 @default.
• W2005072332 hasConceptScore W2005072332C502942594 @default.
• W2005072332 hasConceptScore W2005072332C54757728 @default.
• W2005072332 hasConceptScore W2005072332C55493867 @default.
• W2005072332 hasConceptScore W2005072332C59157529 @default.
• W2005072332 hasConceptScore W2005072332C86339819 @default.
• W2005072332 hasConceptScore W2005072332C86803240 @default.
• W2005072332 hasConceptScore W2005072332C95444343 @default.
• W2005072332 hasIssue "1" @default.
• W2005072332 hasLocation W20050723321 @default.
• W2005072332 hasLocation W20050723322 @default.
• W2005072332 hasOpenAccess W2005072332 @default.
• W2005072332 hasPrimaryLocation W20050723321 @default.

• next