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• W2005073389 abstract "The goal of this study was to evaluate the permeability characteristics of Calu-3, human bronchial epithelial cells to passive and actively transported drugs and to correlate the data with other in vitro models and rat lung absorption in vivo. Air-interface cultured Calu-3 cells grown on collagen-coated permeable filter supports formed tight polarized and well differentiated cell monolayers with apical microvilli and tight-junctional complexes. Within 8-10 days, cell monolayers developed transepithelial electrical resistance (TEER)>1000 ohm cm 2 and potential difference about 11-16 mV. Solute permeability was dependent on lipophilicity, and inversely related to molecular size. Calu-3 cells actively transported amino acids, nucleosides and dipeptide analogs, but not organic anions, organic cations or efflux pump substrates. The permeability characteristics of Calu-3 cells correlated well with primary cultured rabbit tracheal epithelial cells in vitro (r 2 =0.91), and the rate of drug absorption from the rat lung in vivo (r 2 =0.94). The absorption predicted from the regression equation correlated well with observed values. In conclusion, in vitro - in vivo correlation studies indicate that the Calu-3 cell culture model is a potentially useful model to predict absorption of inhalation delivery drug candidates." @default.
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• W2005073389 date "2002-01-01" @default.
• W2005073389 modified "2023-10-09" @default.
• W2005073389 title "Permeability Characteristics of Calu-3 Human Bronchial Epithelial Cells: In Vitro - In Vivo Correlation to Predict Lung Absorption in Rats" @default.
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• W2005073389 doi "https://doi.org/10.1080/10611860290007504" @default.
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