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- W2005076370 abstract "The gene regulation function (GRF) provides an operational description of a promoter behavior as a function of the concentration of one of its transcriptional regulators. Behind this apparently trivial definition lies a central concept in biological control: the GRF provides the input/output relationship of each edge in a transcriptional network, independently from the molecular interactions involved. Here we discuss how existing methods allow direct measurement of the GRF, and how several trade-offs between scalability and accuracy have hindered its application to relatively large networks. We discuss the theoretical and technical requirements for obtaining the GRF. Based on these requirements, we introduce a simplified and easily scalable method that is able to capture the significant parameters of the GRF. The GRF is able to predict the behavior of a simple genetic circuit, illustrating how addressing the quantitative nature of gene regulation substantially increases our comprehension on the mechanisms of gene control." @default.
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- W2005076370 date "2010-03-26" @default.
- W2005076370 modified "2023-10-16" @default.
- W2005076370 title "Numbers on the edges: A simplified and scalable method for quantifying the Gene Regulation Function" @default.
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- W2005076370 doi "https://doi.org/10.1002/bies.200900164" @default.
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