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- W2005087262 abstract "Abstract In order to establish that racemization of the keto-analog of l (+)-isoleucine occurs in vivo, 3–5 mmol/kg of nearly pure optically active S(+)- α-keto-β-methylvalerate was injected intravenously in intact dogs and sequential measurements of its concentration and optical activity in plasma were made by isolating the compound as its 2,4-dinitrophenyl-hydrazone. Disappearance from plasma was exponential at a rate of 0.0824 ± 0.0035 min−1; its volume of distribution was 31 ± 1% of body weight. The average concentration of the R(−)-enantiomer, expressed as percentage of total ketoacid, increased from an initial value of 3.4 to 21.5% at 35 min. Plasma levels of isoleucine and alloisoleucine rose rapidly (to approximately 1.6 and 0.25 m m , respectively), but alloisoleucine reached a peak later and decayed much more slowly. The results demonstrate the existence of a biological mechanism of racemization of S(+)-α-keto-β-methylvaleric acid in the dog. This compound is rapidly cleared from plasma and a substantial proportion is rapidly transaminated to yield both isoleucine and alloisoleucine." @default.
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- W2005087262 date "1977-04-01" @default.
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- W2005087262 title "Racemization and amination of the keto-analog of isoleucine in the intact dog" @default.
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- W2005087262 doi "https://doi.org/10.1016/0006-2944(77)90020-5" @default.
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