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• W2005087886 startingPage "149" @default.
• W2005087886 abstract "In the present study, mice lacking the type 1 inositol-1,4,5-trisphosphate receptor (IP 3 R) were used to study the role of type 1 IP 3 Rs in the induction of long-term potentiation (LTP) in hippocampal CA1 neurons. The magnitude of the LTP induced by high frequency stimulation (HFS) consisting of 20 pulses at 30 Hz in mice lacking type 1 IP 3 Rs was significantly larger than that in wild-type mice in terms of the field excitatory postsynaptic potential and population spike. By measuring changes in the intracellular Ca 2+ concentration ([Ca 2+ ] i ) in CA1 pyramidal neurons using fluorometry, we found that the decay time of the transient increase in the [Ca 2+ ] i evoked by the HFS in mutant mice was significantly longer than that in wild-type mice, whereas the [Ca 2+ ] i at rest and the magnitude of the [Ca 2+ ] i increases caused by the HFS were no different from those in wild-type mice. In slices from the mutant mice, paired-pulse stimulation (PPS) delivered at an interval of 10 ms resulted in significantly weaker paired-pulse inhibition (PPI) than in wild-type mice, suggesting that lack of type 1 IP 3 Rs reduces the PPI induced by PPS in the CA1 region. These results indicate that a lack of type 1 IP 3 Rs causes a slower decay of the transient [Ca 2+ ] i in CA1 pyramidal neurons and attenuates the activity of inhibitory interneurons , resulting in enhancement of LTP induction." @default.
• W2005087886 created "2016-06-24" @default.
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• W2005087886 date "2010-06-01" @default.
• W2005087886 modified "2023-09-26" @default.
• W2005087886 title "Intracellular calcium ion dynamics involved in long-term potentiation in hippocampal CA1 neurons in mice lacking the IP3 type 1 receptor" @default.
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• W2005087886 doi "https://doi.org/10.1016/j.neures.2010.03.002" @default.
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