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- W2005093091 abstract "Selectively substituted 3-oxo-4-substituted 1,2,5-thiadiazolidine 1,1-dioxides (2, four examples), and 3-imino-4-substituted 1,2,5-thiadiazolidine 1,1-dioxides (3, eight examples) have been evaluated in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole seizure threshold (scMet), and rotorod (Tox) tests. These compounds can be considered as sulfonyl analogues of hydantoins (1). In those cases where comparison between 1 and 2 (or 1 and 3) was possible, replacement of the central carbonyl group in 1 by a sulfonyl moiety led to a significant reduction or abolition of the anticonvulsant activity." @default.
- W2005093091 created "2016-06-24" @default.
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- W2005093091 date "1990-08-01" @default.
- W2005093091 modified "2023-09-25" @default.
- W2005093091 title "Anticonvulsant Properties of 3-Oxo- and 3-Imino-4-Substituted 1,2,5-Thiadiazolidine 1,1-Dioxides" @default.
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- W2005093091 doi "https://doi.org/10.1002/jps.2600790813" @default.
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