Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005096752> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2005096752 endingPage "253" @default.
- W2005096752 startingPage "251" @default.
- W2005096752 abstract "CELL mediated immune reactions in mice involving cytotoxic thymus derived lymphocytes have two important features; they are antigen-specific1 and the structures coded for by the major murine histocompatibility gene complex (H–2) play an important part in killer cell-target cell interaction1. This finding is not unique to mice since it has also been reported for rats, humans and chickens2–4. Two hypotheses have been suggested to explain this dual specificity of T killer cells; one proposes that T killer cells possess two separate structures, one of which recognises self H–2 structures and the other a non-H–2 antigen (dual recognition). The other hypothesis proposes that T killer cells possess one receptor which recognises an H–2 antigen modified by a non-H–2 antigen (modified self)1,5. Evidence to test these hypotheses was sought by preparing chimaeras made by reconstituting lethally irradiated F1 mice with bone marrow stem cells of one parent (Parent→F) refs 6–8) or neonatally tolerant mice9 (mice of a parental H–2 type injected with F1 cells as neonates). As a result, Parent → F1 chimaeric lymphocytes lysed infected and trinitrophenyl (TNP)-modified targets of both parental H–2 types, suggesting that H–2 antigens of the killer cells were not involved in the lytic interaction. In contrast, lymphocytes from neonatally tolerant mice did not lyse infected targets from the incompatible parent9. Although these results can be explained by postulating a single receptor, they also fit the dual recognition hypothesis6–10. Bevan has shown that irradiated bone marrow chimaeras of the type (A × B)F1 → Parental A recipient generated preferentially cytotoxic T cells against minor histocompatibility antigens in association with the H–2 haplotype of the recipient A; he concluded that the chimaeric host determines the specificity of T cell restriction either through a thymic selection process as proposed by Jerne or alternatively through an antigen presentation mechanism." @default.
- W2005096752 created "2016-06-24" @default.
- W2005096752 creator A5012400312 @default.
- W2005096752 creator A5047528427 @default.
- W2005096752 creator A5057241233 @default.
- W2005096752 creator A5071908815 @default.
- W2005096752 date "1978-01-01" @default.
- W2005096752 modified "2023-09-23" @default.
- W2005096752 title "Cytotoxic T cells learn specificity for self H–2 during differentiation in the thymus" @default.
- W2005096752 cites W1554912114 @default.
- W2005096752 cites W1609266768 @default.
- W2005096752 cites W1982817758 @default.
- W2005096752 cites W1998240361 @default.
- W2005096752 cites W2024251508 @default.
- W2005096752 cites W2036874582 @default.
- W2005096752 cites W2040289923 @default.
- W2005096752 cites W2080909530 @default.
- W2005096752 cites W2119026807 @default.
- W2005096752 cites W2121285814 @default.
- W2005096752 cites W2131467024 @default.
- W2005096752 cites W2154131040 @default.
- W2005096752 cites W82941063 @default.
- W2005096752 doi "https://doi.org/10.1038/271251a0" @default.
- W2005096752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/304527" @default.
- W2005096752 hasPublicationYear "1978" @default.
- W2005096752 type Work @default.
- W2005096752 sameAs 2005096752 @default.
- W2005096752 citedByCount "207" @default.
- W2005096752 countsByYear W20050967522012 @default.
- W2005096752 countsByYear W20050967522013 @default.
- W2005096752 countsByYear W20050967522014 @default.
- W2005096752 countsByYear W20050967522015 @default.
- W2005096752 countsByYear W20050967522017 @default.
- W2005096752 countsByYear W20050967522022 @default.
- W2005096752 crossrefType "journal-article" @default.
- W2005096752 hasAuthorship W2005096752A5012400312 @default.
- W2005096752 hasAuthorship W2005096752A5047528427 @default.
- W2005096752 hasAuthorship W2005096752A5057241233 @default.
- W2005096752 hasAuthorship W2005096752A5071908815 @default.
- W2005096752 hasBestOaLocation W20050967521 @default.
- W2005096752 hasConcept C147483822 @default.
- W2005096752 hasConcept C153911025 @default.
- W2005096752 hasConcept C154317977 @default.
- W2005096752 hasConcept C182615771 @default.
- W2005096752 hasConcept C188280979 @default.
- W2005096752 hasConcept C202751555 @default.
- W2005096752 hasConcept C202965653 @default.
- W2005096752 hasConcept C203014093 @default.
- W2005096752 hasConcept C207936829 @default.
- W2005096752 hasConcept C2522874641 @default.
- W2005096752 hasConcept C2780007613 @default.
- W2005096752 hasConcept C54355233 @default.
- W2005096752 hasConcept C86803240 @default.
- W2005096752 hasConcept C8891405 @default.
- W2005096752 hasConcept C95444343 @default.
- W2005096752 hasConceptScore W2005096752C147483822 @default.
- W2005096752 hasConceptScore W2005096752C153911025 @default.
- W2005096752 hasConceptScore W2005096752C154317977 @default.
- W2005096752 hasConceptScore W2005096752C182615771 @default.
- W2005096752 hasConceptScore W2005096752C188280979 @default.
- W2005096752 hasConceptScore W2005096752C202751555 @default.
- W2005096752 hasConceptScore W2005096752C202965653 @default.
- W2005096752 hasConceptScore W2005096752C203014093 @default.
- W2005096752 hasConceptScore W2005096752C207936829 @default.
- W2005096752 hasConceptScore W2005096752C2522874641 @default.
- W2005096752 hasConceptScore W2005096752C2780007613 @default.
- W2005096752 hasConceptScore W2005096752C54355233 @default.
- W2005096752 hasConceptScore W2005096752C86803240 @default.
- W2005096752 hasConceptScore W2005096752C8891405 @default.
- W2005096752 hasConceptScore W2005096752C95444343 @default.
- W2005096752 hasIssue "5642" @default.
- W2005096752 hasLocation W20050967521 @default.
- W2005096752 hasLocation W20050967522 @default.
- W2005096752 hasOpenAccess W2005096752 @default.
- W2005096752 hasPrimaryLocation W20050967521 @default.
- W2005096752 hasRelatedWork W1989247143 @default.
- W2005096752 hasRelatedWork W2024251508 @default.
- W2005096752 hasRelatedWork W2099693096 @default.
- W2005096752 hasRelatedWork W2147236666 @default.
- W2005096752 hasRelatedWork W2159306178 @default.
- W2005096752 hasRelatedWork W2220102944 @default.
- W2005096752 hasRelatedWork W2409441623 @default.
- W2005096752 hasRelatedWork W2418616139 @default.
- W2005096752 hasRelatedWork W4210976760 @default.
- W2005096752 hasRelatedWork W773424912 @default.
- W2005096752 hasVolume "271" @default.
- W2005096752 isParatext "false" @default.
- W2005096752 isRetracted "false" @default.
- W2005096752 magId "2005096752" @default.
- W2005096752 workType "article" @default.