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- W2005103419 abstract "The Cucurbitaceae plant Momordica charantia L. is widely cultivated as a vegetable crop in many Asian and African countries. In Chinese, Indian Ayurvedic, and Indonesian Jamu traditional medicines, the fruits, leaves and roots of M. charantia have been used for the treatment of a number of diseases, as a bitter stomachic, a laxative, an antidiabetic, and an anthelmintic for children. It also has a long history of use as a hypoglycemic agent in Asia, and the extract of fruits has been referred to as vegetable insulin [1]. In view of the reported pharmacological significance of this plant, studies were undertaken on the major constituents of the methanolic extract of the fruits. One novel cucurbitane type triterpene glycoside (10) [2] along with nine known cucurbitane type triterpene aglycone (7) [3] and glycosides (1–6, 8, 9) [4] were isolated, and their structures were elucidated by use of 1H-NMR, 13C-NMR, COSY, HMQC, HMBC and HR ESI-MS as well as by comparison with reported data. Acknowledgements: This work is supported by FDA (Grant number 2 U01 FD 002071-07). References: [1] Ethan B, et al. (2003) Am J Health-Syst Pharm. 60: 356–359. [2] Liva H, et al. (2006) Chem. Pharm. Bull. 54: 1017–1021. [3] Fatope M, et al. (1990) J. N. P. 53: 1491–1497. [4] Toshiyuki M, et al. (2001) Chem. Pharm. Bull. 49: 54–63." @default.
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- W2005103419 date "2008-02-01" @default.
- W2005103419 modified "2023-09-26" @default.
- W2005103419 title "A Novel Cucurbitane type triterpenoid from Momordica charantia L." @default.
- W2005103419 doi "https://doi.org/10.1055/s-2008-1075308" @default.
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