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• W2005105145 abstract "High-resolution 1H NMR spectroscopy is frequently used in the field of metabolomics to assess the metabolites found in biofluids or tissue extracts to define a metabolic profile that describes a given biological process. In this study, we aimed to increase the utility of NMR-based metabolomics by using advanced Bayesian modeling of the time-domain high-resolution 1D NMR free induction decay (FID). The improvement over traditional nonparametric binning is twofold and associated with enhanced resolution of the analysis and automation of the signal processing stage. The automation is achieved by using a Bayesian formalism for all parameters of the model including the number of components. The approach is illustrated with a study of early markers of acute exposure to different doses of a well-characterized nongenotoxic hepatocarcinogen, phenobarbital, in rats. The results demonstrate that Bayesian deconvolution produces a better model for the NMR spectra that allows the identification of subtle changes in metabolic concentrations and a decrease in the expected false discovery rate compared with approaches based on “binning”. These properties suggest that Bayesian deconvolution could facilitate the biomarker discovery process and improve information extraction from high-resolution NMR spectra." @default.
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• W2005105145 date "2010-05-06" @default.
• W2005105145 modified "2023-10-07" @default.
• W2005105145 title "Application of a Bayesian Deconvolution Approach for High-Resolution ¹H NMR Spectra to Assessing the Metabolic Effects of Acute Phenobarbital Exposure in Liver Tissue" @default.
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• W2005105145 doi "https://doi.org/10.1021/ac100344m" @default.
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