FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005110124> ?p ?o ?g. }

• W2005110124 endingPage "4578" @default.
• W2005110124 startingPage "4571" @default.
• W2005110124 abstract "Glucokinase activators are a class of experimental agents under investigation as a therapy for Type 2 diabetes mellitus. An X-ray crystal structure of a modestly potent agent revealed the potential to substitute the common heterocyclic amide donor–acceptor motif for a pyridone moiety. We have successfully demonstrated that both pyridone and pyrimidone heterocycles can be used as a potent donor–acceptor substituent. Several sub-micromolar analogs that possess the desired partial activator profile were synthesized and characterized. Unfortunately, the most potent activators suffered from sub-optimal pharmacokinetic properties. Nonetheless, these donor–acceptor motifs may find utility in other glucokinase activator series or beyond." @default.
• W2005110124 created "2016-06-24" @default.
• W2005110124 creator A5001644611 @default.
• W2005110124 creator A5011697275 @default.
• W2005110124 creator A5013022553 @default.
• W2005110124 creator A5013806567 @default.
• W2005110124 creator A5024720734 @default.
• W2005110124 creator A5040346731 @default.
• W2005110124 creator A5041835896 @default.
• W2005110124 creator A5045322500 @default.
• W2005110124 creator A5048881982 @default.
• W2005110124 creator A5049945495 @default.
• W2005110124 creator A5051505165 @default.
• W2005110124 creator A5054166388 @default.
• W2005110124 creator A5057508297 @default.
• W2005110124 creator A5061752577 @default.
• W2005110124 creator A5067896533 @default.
• W2005110124 creator A5069371997 @default.
• W2005110124 creator A5070675668 @default.
• W2005110124 creator A5073868581 @default.
• W2005110124 creator A5077877881 @default.
• W2005110124 creator A5079455571 @default.
• W2005110124 creator A5080710161 @default.
• W2005110124 creator A5088845829 @default.
• W2005110124 creator A5054236978 @default.
• W2005110124 date "2013-08-01" @default.
• W2005110124 modified "2023-10-16" @default.
• W2005110124 title "Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif" @default.
• W2005110124 cites W1556415950 @default.
• W2005110124 cites W1792096775 @default.
• W2005110124 cites W1966105870 @default.
• W2005110124 cites W1973375291 @default.
• W2005110124 cites W1976278317 @default.
• W2005110124 cites W1982600501 @default.
• W2005110124 cites W1988137261 @default.
• W2005110124 cites W1990520277 @default.
• W2005110124 cites W1992960970 @default.
• W2005110124 cites W2008525757 @default.
• W2005110124 cites W2013481385 @default.
• W2005110124 cites W2018823964 @default.
• W2005110124 cites W2031149113 @default.
• W2005110124 cites W2037809940 @default.
• W2005110124 cites W2050051162 @default.
• W2005110124 cites W2062458432 @default.
• W2005110124 cites W2070793266 @default.
• W2005110124 cites W2074153623 @default.
• W2005110124 cites W2084762332 @default.
• W2005110124 cites W2111132082 @default.
• W2005110124 cites W2112040506 @default.
• W2005110124 cites W2134141050 @default.
• W2005110124 cites W2153041556 @default.
• W2005110124 cites W2164306929 @default.
• W2005110124 cites W2176018649 @default.
• W2005110124 cites W2331730239 @default.
• W2005110124 cites W2335043794 @default.
• W2005110124 cites W4234063371 @default.
• W2005110124 doi "https://doi.org/10.1016/j.bmcl.2013.06.036" @default.
• W2005110124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23831135" @default.
• W2005110124 hasPublicationYear "2013" @default.
• W2005110124 type Work @default.
• W2005110124 sameAs 2005110124 @default.
• W2005110124 citedByCount "18" @default.
• W2005110124 countsByYear W20051101242014 @default.
• W2005110124 countsByYear W20051101242016 @default.
• W2005110124 countsByYear W20051101242017 @default.
• W2005110124 countsByYear W20051101242018 @default.
• W2005110124 countsByYear W20051101242019 @default.
• W2005110124 countsByYear W20051101242020 @default.
• W2005110124 countsByYear W20051101242021 @default.
• W2005110124 countsByYear W20051101242022 @default.
• W2005110124 countsByYear W20051101242023 @default.
• W2005110124 crossrefType "journal-article" @default.
• W2005110124 hasAuthorship W2005110124A5001644611 @default.
• W2005110124 hasAuthorship W2005110124A5011697275 @default.
• W2005110124 hasAuthorship W2005110124A5013022553 @default.
• W2005110124 hasAuthorship W2005110124A5013806567 @default.
• W2005110124 hasAuthorship W2005110124A5024720734 @default.
• W2005110124 hasAuthorship W2005110124A5040346731 @default.
• W2005110124 hasAuthorship W2005110124A5041835896 @default.
• W2005110124 hasAuthorship W2005110124A5045322500 @default.
• W2005110124 hasAuthorship W2005110124A5048881982 @default.
• W2005110124 hasAuthorship W2005110124A5049945495 @default.
• W2005110124 hasAuthorship W2005110124A5051505165 @default.
• W2005110124 hasAuthorship W2005110124A5054166388 @default.
• W2005110124 hasAuthorship W2005110124A5054236978 @default.
• W2005110124 hasAuthorship W2005110124A5057508297 @default.
• W2005110124 hasAuthorship W2005110124A5061752577 @default.
• W2005110124 hasAuthorship W2005110124A5067896533 @default.
• W2005110124 hasAuthorship W2005110124A5069371997 @default.
• W2005110124 hasAuthorship W2005110124A5070675668 @default.
• W2005110124 hasAuthorship W2005110124A5073868581 @default.
• W2005110124 hasAuthorship W2005110124A5077877881 @default.
• W2005110124 hasAuthorship W2005110124A5079455571 @default.
• W2005110124 hasAuthorship W2005110124A5080710161 @default.
• W2005110124 hasAuthorship W2005110124A5088845829 @default.
• W2005110124 hasConcept C121332964 @default.
• W2005110124 hasConcept C132677234 @default.
• W2005110124 hasConcept C170493617 @default.

• next