FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005115756> ?p ?o ?g. }

• W2005115756 endingPage "382" @default.
• W2005115756 startingPage "377" @default.
• W2005115756 abstract "While GABA and glutamate have an established synaptic function in the CNS, recent evidence suggests 5-HT neurotransmission is predominantly paracrine. As the amino-acid neurotransmitters interact with receptors that produce effects rapidly, electrophysiological approaches can be used to assess the time delay between transmitter release and the postsynaptic response directly. However, this approach cannot be used for studies of 5-HT-mediated neurotransmission, because the majority of its receptors react more slowly, so anatomical and voltammetrical approaches have been used to provide insight into 5-HT-mediated events. These studies have revealed that extrasynaptic receptors and transporters for 5-HT exist, and that 5-HT escapes readily from the synaptic cleft. Attenuation of 5-HT binding by 5-HT-receptor antagonists and 5-HT-uptake inhibitors does not affect the synaptic efflux elicited by transient stimuli, although the effects of such drugs are apparent at later time points. Once it is extrasynaptic, 5-HT has a concentration that is similar to those estimated to be optimal for receptor and transporter activation, and it can diffuse a few micrometers until removed by its transporter. These properties of 5-HT raise the possibility that it can act on receptors that are distant from its release site and function as a paracrine transmitter." @default.
• W2005115756 created "2016-06-24" @default.
• W2005115756 creator A5060135640 @default.
• W2005115756 creator A5082362881 @default.
• W2005115756 date "1999-09-01" @default.
• W2005115756 modified "2023-10-08" @default.
• W2005115756 title "Paracrine neurotransmission in the CNS: involvement of 5-HT" @default.
• W2005115756 cites W1505903665 @default.
• W2005115756 cites W1591523569 @default.
• W2005115756 cites W1854755157 @default.
• W2005115756 cites W1865166881 @default.
• W2005115756 cites W1948828760 @default.
• W2005115756 cites W1967458028 @default.
• W2005115756 cites W1967763633 @default.
• W2005115756 cites W1972829230 @default.
• W2005115756 cites W1975888261 @default.
• W2005115756 cites W1979116433 @default.
• W2005115756 cites W1993391624 @default.
• W2005115756 cites W1993861337 @default.
• W2005115756 cites W2003059369 @default.
• W2005115756 cites W2006415628 @default.
• W2005115756 cites W2006431157 @default.
• W2005115756 cites W2007239691 @default.
• W2005115756 cites W2009759632 @default.
• W2005115756 cites W2014793858 @default.
• W2005115756 cites W2027671925 @default.
• W2005115756 cites W2030352252 @default.
• W2005115756 cites W2035632600 @default.
• W2005115756 cites W2042903064 @default.
• W2005115756 cites W2043923378 @default.
• W2005115756 cites W2054265484 @default.
• W2005115756 cites W2060109954 @default.
• W2005115756 cites W2063261415 @default.
• W2005115756 cites W2066562577 @default.
• W2005115756 cites W2067866417 @default.
• W2005115756 cites W2086399192 @default.
• W2005115756 cites W2094089753 @default.
• W2005115756 cites W2107543249 @default.
• W2005115756 cites W2112075758 @default.
• W2005115756 cites W2126033464 @default.
• W2005115756 cites W2128744963 @default.
• W2005115756 cites W2146670556 @default.
• W2005115756 cites W2153499119 @default.
• W2005115756 cites W2171788395 @default.
• W2005115756 cites W2244880663 @default.
• W2005115756 cites W2314458477 @default.
• W2005115756 cites W2340859740 @default.
• W2005115756 cites W2399052258 @default.
• W2005115756 cites W2408118606 @default.
• W2005115756 cites W2414121740 @default.
• W2005115756 doi "https://doi.org/10.1016/s0166-2236(99)01410-1" @default.
• W2005115756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10441294" @default.
• W2005115756 hasPublicationYear "1999" @default.
• W2005115756 type Work @default.
• W2005115756 sameAs 2005115756 @default.
• W2005115756 citedByCount "170" @default.
• W2005115756 countsByYear W20051157562012 @default.
• W2005115756 countsByYear W20051157562013 @default.
• W2005115756 countsByYear W20051157562014 @default.
• W2005115756 countsByYear W20051157562015 @default.
• W2005115756 countsByYear W20051157562016 @default.
• W2005115756 countsByYear W20051157562017 @default.
• W2005115756 countsByYear W20051157562018 @default.
• W2005115756 countsByYear W20051157562019 @default.
• W2005115756 countsByYear W20051157562020 @default.
• W2005115756 countsByYear W20051157562021 @default.
• W2005115756 countsByYear W20051157562022 @default.
• W2005115756 countsByYear W20051157562023 @default.
• W2005115756 crossrefType "journal-article" @default.
• W2005115756 hasAuthorship W2005115756A5060135640 @default.
• W2005115756 hasAuthorship W2005115756A5082362881 @default.
• W2005115756 hasConcept C169760540 @default.
• W2005115756 hasConcept C170493617 @default.
• W2005115756 hasConcept C185592680 @default.
• W2005115756 hasConcept C197341189 @default.
• W2005115756 hasConcept C200170125 @default.
• W2005115756 hasConcept C2775864247 @default.
• W2005115756 hasConcept C2776219046 @default.
• W2005115756 hasConcept C2780375056 @default.
• W2005115756 hasConcept C529278444 @default.
• W2005115756 hasConcept C53910766 @default.
• W2005115756 hasConcept C55493867 @default.
• W2005115756 hasConcept C61174792 @default.
• W2005115756 hasConcept C7876069 @default.
• W2005115756 hasConcept C86803240 @default.
• W2005115756 hasConcept C95444343 @default.
• W2005115756 hasConceptScore W2005115756C169760540 @default.
• W2005115756 hasConceptScore W2005115756C170493617 @default.
• W2005115756 hasConceptScore W2005115756C185592680 @default.
• W2005115756 hasConceptScore W2005115756C197341189 @default.
• W2005115756 hasConceptScore W2005115756C200170125 @default.
• W2005115756 hasConceptScore W2005115756C2775864247 @default.
• W2005115756 hasConceptScore W2005115756C2776219046 @default.
• W2005115756 hasConceptScore W2005115756C2780375056 @default.
• W2005115756 hasConceptScore W2005115756C529278444 @default.
• W2005115756 hasConceptScore W2005115756C53910766 @default.
• W2005115756 hasConceptScore W2005115756C55493867 @default.
• W2005115756 hasConceptScore W2005115756C61174792 @default.

• next