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- W2005117629 abstract "Abstract Methadone maintenance is the premier pharmacological treatment for opioid addiction, but it is rarely informed by evidence-based practice guidelines for dosage monitoring and adjustment. Such guidelines are crucial because the pharmacokinetics of methadone vary greatly among patients, and this variation may account for differences in treatment outcome. We review the pharmacokinetics of methadone and factors that may alter it (including drug interactions, disease states, and idiosyncratic differences among patients). Also reviewed are prospects for therapeutic drug monitoring (TDM) of methadone in plasma, urine, sweat, and saliva. Due to its ease of collection and its presumed representation of the bioavailable free-fraction of methadone, saliva may be a promising matrix. However, saliva methadone concentrations are influenced by salivary pH, and future studies are needed to determine how to control for that. Administrative, medical, and social implications of methadone TDM are briefly discussed." @default.
- W2005117629 created "2016-06-24" @default.
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- W2005117629 creator A5040672500 @default.
- W2005117629 creator A5068183964 @default.
- W2005117629 date "2001-04-02" @default.
- W2005117629 modified "2023-10-10" @default.
- W2005117629 title "Therapeutic Drug Monitoring in Methadone Maintenance" @default.
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- W2005117629 doi "https://doi.org/10.1300/j069v20n02_05" @default.
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