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• W2005118045 abstract "Optical systems could be valuable tools for assessing cerebral function at the cotsideThe newborn brain is vulnerable to a variety of insults with potentially lifelong consequences. As our understanding of the mechanism of brain injury improves and new therapies are developed to prevent or minimise brain injury, new non-invasive methods are required to assess cerebral function at the cotside.The application of near-infrared spectroscopy (NIRS) for continuous monitoring of cerebral haemodynamics and oxygenation non-invasively was first reported by Jobsis in 1977.1 Since that time NIRS has become an effective research tool for studying infant cerebral haemodynamics and oxygenation.2,3 NIRS exploits the relative transparency of biological tissue to near-infrared light (700–1000 nm), and the wavelength-dependent absorption characteristics of haemoglobin, which vary with oxygenation. By monitoring the intensity of light passing through brain tissue at two or more wavelengths, observed changes in attenuation can be converted into changes in the cerebral concentrations of oxyhaemoglobin and deoxyhaemoglobin.An obvious application of NIRS is the investigation of localised changes in oxyhaemoglobin and deoxyhaemoglobin resulting from functional activation of the cerebral cortex. Increases in local cerebral blood flow (CBF) are manifested by a rise in oxyhaemoglobin and a fall in deoxyhaemoglobin whereas oxygen consumption during activation results in a decrease in oxyhaemoglobin and an increase in deoxyhaemoglobin. The balance between local perfusion and consumption can be investigated with NIRS.The first functional studies in the newborn with optical techniques used conventional single source-detector systems to measure overall changes in oxygenation over a particular area of the head. Meek et al reported that, in response to a visual stimulus, there was an increase in both oxyhaemoglobin and deoxyhaemoglobin over the occipital lobe.4 This finding was consistent with those of studies in infants using functional MRI and contrasted with the response in …" @default.
• W2005118045 created "2016-06-24" @default.
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• W2005118045 date "2007-01-24" @default.
• W2005118045 modified "2023-09-27" @default.
• W2005118045 title "Optical imaging of the neonatal brain" @default.
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• W2005118045 doi "https://doi.org/10.1136/adc.2006.103846" @default.
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