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- W2005120164 abstract "<h3>To the Editor.—</h3> After reading the excellent article by Mattson et al<sup>1</sup>on oral contraception use in epileptic women, I would like to raise the following points. The authors discuss valproic acid (Depakene) from the standpoint of decreased incidence of breakthrough bleeding, but fail to mention studies linking its use in pregnancy to a 2% risk of neural tube defects. This level of risk has prompted the Centers for Disease Control to establish a regist registry for women receiving valproate during pregnancy.<sup>2</sup>It would seem reasonable that this particular anticonvulsant be avoided and used only as a last resort. While the authors acknowledge the tenuous link between breakthrough bleeding and oral contraceptive efficacy, the relatively high rate of breakthrough bleeding in the patient population discussed makes it a real concern for both clinician and patient. The recommendation to switch from a 30or 40-μg preparation to 50 μg of" @default.
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- W2005120164 date "1986-12-05" @default.
- W2005120164 modified "2023-10-16" @default.
- W2005120164 title "Use of Oral Contraceptives by Women With Epilepsy" @default.
- W2005120164 cites W2019369679 @default.
- W2005120164 doi "https://doi.org/10.1001/jama.1986.03380210057017" @default.
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