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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005120423> ?p ?o ?g. }

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• W2005120423 abstract "These results show that eight pancreatic cancer cell lines are broadly sensitive to CDDP, and that chemotherapy for pancreatic cancer may improve the prognosis by more effective drug delivery to cancer cells. Chemotherapy for pancreatic cancer does not satisfactorily improve prognosis. The efficacy of chemotherapy depends on choosing sensitive anticancer drugs. The in vitro chemosensitivity of eight human pancreatic cancer cell lines was investigated. Growth inhibition was measured by3H-thymidine incorporation assays for doxorubicin hydrochloride (ADM), mitomycin C (MMC), cisplatin (CDDP), and etoposide (VP-16), and by Alamar BlueTM assay for (AB assay) 5-fluorouracil (5-FU). The cells were exposed to ADM, MMC, CDDP, and VP-16 for 2h, and 5-FU for 72 h. From the dose-response curves, the 50% growth inhibition (IC50) level for each drug was estimated. The IC50 after 2 h of exposure of each of the eight kinds of cell lines to each anticancer drug ranged from 0.12–8.2 μg/mL for ADM, 0.066–25 μg/mL for MMC, 0.57–7 μg/mL for CDDP, 0.68–300 μg/mL for VP-16. IC50 after 72 h of exposure to 5-FU ranged from 1.8–23 μg/mL." @default.
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• W2005120423 date "1996-12-01" @default.
• W2005120423 modified "2023-10-18" @default.
• W2005120423 title "In vitro chemosensitivity of human pancreatic cancer cell lines" @default.
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• W2005120423 doi "https://doi.org/10.1007/bf02803767" @default.
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