FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005120531> ?p ?o ?g. }

• W2005120531 endingPage "90" @default.
• W2005120531 startingPage "82" @default.
• W2005120531 abstract "Nanoparticles can be administered via nasal, oral, intraocular, intratracheal (pulmonary toxicity), tail vein and other routes. Here, we focus on the time-dependent translocation and potential damage of TiO 2 nanoparticles on central nervous system (CNS) through intranasal instillation. Size and structural properties are important to assess biological effects of TiO 2 nanoparticles. In present study, female mice were intranasally instilled with two types of well-characterized TiO 2 nanoparticles (i.e. 80 nm, rutile and 155 nm, anatase; purity > 99%) every other day. Pure water instilled mice were served as controls. The brain tissues were collected and evaluated for accumulation and distribution of TiO 2 , histopathology, oxidative stress, and inflammatory markers at post-instillation time points of 2, 10, 20 and 30 days. The titanium contents in the sub-brain regions including olfactory bulb, cerebral cortex, hippocampus, and cerebellum were determined by inductively coupled plasma mass spectrometry (ICP-MS). Results indicated that the instilled TiO 2 directly entered the brain through olfactory bulb in the whole exposure period, especially deposited in the hippocampus region. After exposure for 30 days, the pathological changes were observed in the hippocampus and olfactory bulb using Nissl staining and transmission electron microscope. The oxidative damage expressed as lipid peroxidation increased significantly, in particular in the exposed group of anatase TiO 2 particles at 30 days postexposure. Exposure to anatase TiO 2 particles also produced higher inflammation responses, in association with the significantly increased tumor necrosis factor alpha (TNF-α) and interleukin (IL-1β) levels. We conclude that subtle differences in responses to anatase TiO 2 particles versus the rutile ones could be related to crystal structure. Thus, based on these results, rutile ultrafine-TiO 2 particles are expected to have a little lower risk potential for producing adverse effects on central nervous system. Although understanding the mechanisms requires further investigation, the present results suggest that we should pay attention to potential risk of occupational exposure for large-scaled production of TiO 2 nanoparticles." @default.
• W2005120531 created "2016-06-24" @default.
• W2005120531 creator A5000432967 @default.
• W2005120531 creator A5004641991 @default.
• W2005120531 creator A5007615595 @default.
• W2005120531 creator A5016909151 @default.
• W2005120531 creator A5023104005 @default.
• W2005120531 creator A5024938458 @default.
• W2005120531 creator A5035192507 @default.
• W2005120531 creator A5060002817 @default.
• W2005120531 creator A5062064300 @default.
• W2005120531 creator A5066029453 @default.
• W2005120531 creator A5073108451 @default.
• W2005120531 creator A5080722498 @default.
• W2005120531 creator A5088951751 @default.
• W2005120531 date "2008-12-01" @default.
• W2005120531 modified "2023-09-30" @default.
• W2005120531 title "Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles" @default.
• W2005120531 cites W180556107 @default.
• W2005120531 cites W1964123007 @default.
• W2005120531 cites W1970735249 @default.
• W2005120531 cites W1972017052 @default.
• W2005120531 cites W1975825403 @default.
• W2005120531 cites W1975837510 @default.
• W2005120531 cites W1976528399 @default.
• W2005120531 cites W1978538970 @default.
• W2005120531 cites W1979093868 @default.
• W2005120531 cites W1990495056 @default.
• W2005120531 cites W1997774266 @default.
• W2005120531 cites W2003753489 @default.
• W2005120531 cites W2006824205 @default.
• W2005120531 cites W2011932089 @default.
• W2005120531 cites W2013065340 @default.
• W2005120531 cites W2014262412 @default.
• W2005120531 cites W2015497529 @default.
• W2005120531 cites W2018368762 @default.
• W2005120531 cites W2031149424 @default.
• W2005120531 cites W2032146145 @default.
• W2005120531 cites W2038735819 @default.
• W2005120531 cites W2039060098 @default.
• W2005120531 cites W2039108854 @default.
• W2005120531 cites W2042400913 @default.
• W2005120531 cites W2044627978 @default.
• W2005120531 cites W2071450341 @default.
• W2005120531 cites W2081572333 @default.
• W2005120531 cites W2085879221 @default.
• W2005120531 cites W2090107650 @default.
• W2005120531 cites W2102122862 @default.
• W2005120531 cites W2108427196 @default.
• W2005120531 cites W2113713722 @default.
• W2005120531 cites W2115123250 @default.
• W2005120531 cites W2117326659 @default.
• W2005120531 cites W2117638652 @default.
• W2005120531 cites W2122021233 @default.
• W2005120531 cites W2140720810 @default.
• W2005120531 cites W2141819645 @default.
• W2005120531 cites W2149848619 @default.
• W2005120531 cites W2155118487 @default.
• W2005120531 cites W2160308360 @default.
• W2005120531 cites W2168598204 @default.
• W2005120531 cites W4293247451 @default.
• W2005120531 doi "https://doi.org/10.1016/j.tox.2008.09.014" @default.
• W2005120531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18929619" @default.
• W2005120531 hasPublicationYear "2008" @default.
• W2005120531 type Work @default.
• W2005120531 sameAs 2005120531 @default.
• W2005120531 citedByCount "372" @default.
• W2005120531 countsByYear W20051205312012 @default.
• W2005120531 countsByYear W20051205312013 @default.
• W2005120531 countsByYear W20051205312014 @default.
• W2005120531 countsByYear W20051205312015 @default.
• W2005120531 countsByYear W20051205312016 @default.
• W2005120531 countsByYear W20051205312017 @default.
• W2005120531 countsByYear W20051205312018 @default.
• W2005120531 countsByYear W20051205312019 @default.
• W2005120531 countsByYear W20051205312020 @default.
• W2005120531 countsByYear W20051205312021 @default.
• W2005120531 countsByYear W20051205312022 @default.
• W2005120531 countsByYear W20051205312023 @default.
• W2005120531 crossrefType "journal-article" @default.
• W2005120531 hasAuthorship W2005120531A5000432967 @default.
• W2005120531 hasAuthorship W2005120531A5004641991 @default.
• W2005120531 hasAuthorship W2005120531A5007615595 @default.
• W2005120531 hasAuthorship W2005120531A5016909151 @default.
• W2005120531 hasAuthorship W2005120531A5023104005 @default.
• W2005120531 hasAuthorship W2005120531A5024938458 @default.
• W2005120531 hasAuthorship W2005120531A5035192507 @default.
• W2005120531 hasAuthorship W2005120531A5060002817 @default.
• W2005120531 hasAuthorship W2005120531A5062064300 @default.
• W2005120531 hasAuthorship W2005120531A5066029453 @default.
• W2005120531 hasAuthorship W2005120531A5073108451 @default.
• W2005120531 hasAuthorship W2005120531A5080722498 @default.
• W2005120531 hasAuthorship W2005120531A5088951751 @default.
• W2005120531 hasConcept C126322002 @default.
• W2005120531 hasConcept C134018914 @default.
• W2005120531 hasConcept C142724271 @default.
• W2005120531 hasConcept C185592680 @default.
• W2005120531 hasConcept C2776151105 @default.

• next