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- W2005120878 abstract "The mucosal immune system defends against a vast array of pathogens, yet it exhibits limited responses to commensal microorganisms under healthy conditions. The oral-pharyngeal cavity, the gateway for both the gastrointestinal and respiratory tracts, is composed of complex anatomical structures and is constantly challenged by antigens from air and food. The mucosal immune system of the oral-pharyngeal cavity must prevent pathogen entry while maintaining immune homeostasis, which is achieved via a range of mechanisms that are similar or different to those utilized by the gastrointestinal immune system. In this review, we summarize the features of the mucosal immune system, focusing on T cell subsets and their functions. We also discuss our current understanding of the oral-pharyngeal mucosal immune system. The diverse immune responses provided by T cells in the lining of the oral cavity have been reviewed by US and Chinese researchers. The oral-pharyngeal cavity is the gateway to the gastrointestinal (GI) and respiratory tracts, and is exposed to microbes, food particles and other substances. The oral mucosal layers contain many different types of T cells that protect against infection but detailed knowledge of their function is limited. WanJun Chen, Qian-Ming Chen and co-workers at the National Institutes of Health in Maryland, and Sichuan University in Chengdu, base their review on the more established knowledge of the GI mucosal system. They find that the oral cavity lining has many similar functions to the lining of the GI but produces some unique signalling proteins. The authors highlight the need for more research into this important immune barrier." @default.
- W2005120878 created "2016-06-24" @default.
- W2005120878 creator A5022849360 @default.
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- W2005120878 creator A5056257750 @default.
- W2005120878 creator A5065972430 @default.
- W2005120878 date "2014-08-08" @default.
- W2005120878 modified "2023-10-18" @default.
- W2005120878 title "The mucosal immune system in the oral cavity—an orchestra of T cell diversity" @default.
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