Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005121454> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2005121454 endingPage "74" @default.
- W2005121454 startingPage "67" @default.
- W2005121454 abstract "Possible involvement of increased mucosal permeability in the stimulation by prostaglandin E2 (PGE2) of duodenal HC03- secretion was investigated in rats. PGE2 (0.3, 1 mg/kg, s.c.) dose-dependently increased HC03- secretion in the duodenum with a significant elevation of transmucosal potential difference (PD); the PD was increased from -4.5±0.3 mV to -10.0±1.5 mV (mucosa negative) at 1 mg/kg. These responses caused by PGE2 were abolished by sacrificing the animals with saturated KCI (i.v.). Although a significant increase of HC03-output was observed after exposure of the mucosa to 1 M NaCI (0.5 ml), this response was accompanied by a significant reduction of PD and was not abolished after KCI injection. The mucosal permeability determined by Evans blue (1%, i.v.) was not affected by PGE2, while 1 M NaCI markedly elevated the amount of extravasated dye in both the luminal content and the mucosa. Stimulation of HC03-output by PGE2 was significantly mitigated by ouabain (3 mg/kg, s.c.) or prior exposure of the mucosa to 1 M NaCI. These results suggest that stimulation by PGE2 of duodenal HC03- secretion is not simply due to the increased mucosal permeability, but depends rather on both the Na/K ATPase activity and the intact perfusion of the organ. The HC03- response as induced by 1 M NaCI may result from the increased permeability and is accompanied by a marked reduction of PD." @default.
- W2005121454 created "2016-06-24" @default.
- W2005121454 creator A5046187913 @default.
- W2005121454 creator A5054212150 @default.
- W2005121454 creator A5088748158 @default.
- W2005121454 creator A5090713682 @default.
- W2005121454 date "1990-01-01" @default.
- W2005121454 modified "2023-09-24" @default.
- W2005121454 title "Stimulation by Prostaglandin E2 of Alkaline Secretion in the Rat Duodenum: Comparative Study with Hypertonic NaCI" @default.
- W2005121454 cites W1977406435 @default.
- W2005121454 cites W1988116517 @default.
- W2005121454 cites W2012757283 @default.
- W2005121454 cites W2019694627 @default.
- W2005121454 cites W2036085875 @default.
- W2005121454 cites W2081515290 @default.
- W2005121454 cites W2095064493 @default.
- W2005121454 cites W2328413501 @default.
- W2005121454 cites W2367706592 @default.
- W2005121454 cites W2411726564 @default.
- W2005121454 cites W2433622190 @default.
- W2005121454 cites W4233076223 @default.
- W2005121454 doi "https://doi.org/10.1254/jjp.53.67" @default.
- W2005121454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2161966" @default.
- W2005121454 hasPublicationYear "1990" @default.
- W2005121454 type Work @default.
- W2005121454 sameAs 2005121454 @default.
- W2005121454 citedByCount "3" @default.
- W2005121454 crossrefType "journal-article" @default.
- W2005121454 hasAuthorship W2005121454A5046187913 @default.
- W2005121454 hasAuthorship W2005121454A5054212150 @default.
- W2005121454 hasAuthorship W2005121454A5088748158 @default.
- W2005121454 hasAuthorship W2005121454A5090713682 @default.
- W2005121454 hasBestOaLocation W20051214541 @default.
- W2005121454 hasConcept C117277713 @default.
- W2005121454 hasConcept C120882062 @default.
- W2005121454 hasConcept C126322002 @default.
- W2005121454 hasConcept C134018914 @default.
- W2005121454 hasConcept C178790620 @default.
- W2005121454 hasConcept C185592680 @default.
- W2005121454 hasConcept C24998067 @default.
- W2005121454 hasConcept C2776809568 @default.
- W2005121454 hasConcept C2777198256 @default.
- W2005121454 hasConcept C2777956040 @default.
- W2005121454 hasConcept C2779133857 @default.
- W2005121454 hasConcept C2780664492 @default.
- W2005121454 hasConcept C3019368612 @default.
- W2005121454 hasConcept C41625074 @default.
- W2005121454 hasConcept C49039625 @default.
- W2005121454 hasConcept C537181965 @default.
- W2005121454 hasConcept C55493867 @default.
- W2005121454 hasConcept C71924100 @default.
- W2005121454 hasConcept C86803240 @default.
- W2005121454 hasConceptScore W2005121454C117277713 @default.
- W2005121454 hasConceptScore W2005121454C120882062 @default.
- W2005121454 hasConceptScore W2005121454C126322002 @default.
- W2005121454 hasConceptScore W2005121454C134018914 @default.
- W2005121454 hasConceptScore W2005121454C178790620 @default.
- W2005121454 hasConceptScore W2005121454C185592680 @default.
- W2005121454 hasConceptScore W2005121454C24998067 @default.
- W2005121454 hasConceptScore W2005121454C2776809568 @default.
- W2005121454 hasConceptScore W2005121454C2777198256 @default.
- W2005121454 hasConceptScore W2005121454C2777956040 @default.
- W2005121454 hasConceptScore W2005121454C2779133857 @default.
- W2005121454 hasConceptScore W2005121454C2780664492 @default.
- W2005121454 hasConceptScore W2005121454C3019368612 @default.
- W2005121454 hasConceptScore W2005121454C41625074 @default.
- W2005121454 hasConceptScore W2005121454C49039625 @default.
- W2005121454 hasConceptScore W2005121454C537181965 @default.
- W2005121454 hasConceptScore W2005121454C55493867 @default.
- W2005121454 hasConceptScore W2005121454C71924100 @default.
- W2005121454 hasConceptScore W2005121454C86803240 @default.
- W2005121454 hasIssue "1" @default.
- W2005121454 hasLocation W20051214541 @default.
- W2005121454 hasLocation W20051214542 @default.
- W2005121454 hasOpenAccess W2005121454 @default.
- W2005121454 hasPrimaryLocation W20051214541 @default.
- W2005121454 hasRelatedWork W2005121454 @default.
- W2005121454 hasRelatedWork W2006844127 @default.
- W2005121454 hasRelatedWork W2016034363 @default.
- W2005121454 hasRelatedWork W2030185139 @default.
- W2005121454 hasRelatedWork W2056100207 @default.
- W2005121454 hasRelatedWork W2058874401 @default.
- W2005121454 hasRelatedWork W2069315580 @default.
- W2005121454 hasRelatedWork W3189266231 @default.
- W2005121454 hasRelatedWork W347809129 @default.
- W2005121454 hasRelatedWork W69844665 @default.
- W2005121454 hasVolume "53" @default.
- W2005121454 isParatext "false" @default.
- W2005121454 isRetracted "false" @default.
- W2005121454 magId "2005121454" @default.
- W2005121454 workType "article" @default.