FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005123037> ?p ?o ?g. }

• W2005123037 endingPage "9" @default.
• W2005123037 startingPage "1" @default.
• W2005123037 abstract "Reported here are 72 previously treated Philadelphia chromosome–positive (Ph+) CML patients on imatinib (IM) therapy, with a focus on patients with additional chromosomal aberrations (CAs). At the start of IM treatment, 49 patients exhibited only the Ph chromosome (68%) and 23 patients (32%) had one or more additional CAs. The most frequent additional changes were deletions on the der(9q) (8 of 23), trisomy 8 (3 of 23), and an extra copy of the Ph chromosome (2 of 23). Five patients had a complex karyotype. At the latest follow-up, 49 of the 72 patients (68%) were alive, including 15 of the 23 patients with additional CAs (65%). Median follow-up was 6.6 years; median duration of IM treatment was 4.4 years. In all, 35 of the 49 patients with Ph only (71%) and 10 of the 23 patients with additional CAs (43%) achieved complete cytogenetic response. All patients with deletion on der(9q) achieved complete cytogenetic response. There was no statistically significant difference in the overall survival of patients with additional CAs and patients with Ph as the sole abnormality. Patients in accelerated phase had significantly worse overall survival on IM, regardless of additional CAs. The present results confirm that the majority of previously treated Ph+ CML patients benefit from starting IM therapy, including patients with defined additional changes. In contrast, patients with complex karyotypes have poor prognosis, even with IM." @default.
• W2005123037 created "2016-06-24" @default.
• W2005123037 creator A5000865985 @default.
• W2005123037 creator A5010946531 @default.
• W2005123037 creator A5017857983 @default.
• W2005123037 creator A5031444581 @default.
• W2005123037 creator A5037131671 @default.
• W2005123037 creator A5045455980 @default.
• W2005123037 creator A5046844133 @default.
• W2005123037 creator A5058444378 @default.
• W2005123037 creator A5060416371 @default.
• W2005123037 creator A5060675816 @default.
• W2005123037 creator A5088310937 @default.
• W2005123037 date "2009-05-01" @default.
• W2005123037 modified "2023-09-26" @default.
• W2005123037 title "Imatinib mesylate efficacy in 72 previously treated Philadelphia-positive chronic myeloid leukemia patients with and without additional chromosomal changes: single-center results" @default.
• W2005123037 cites W1964358866 @default.
• W2005123037 cites W1972804480 @default.
• W2005123037 cites W1999048322 @default.
• W2005123037 cites W1999315111 @default.
• W2005123037 cites W2001313342 @default.
• W2005123037 cites W2002897447 @default.
• W2005123037 cites W2013852856 @default.
• W2005123037 cites W2014205306 @default.
• W2005123037 cites W2015616444 @default.
• W2005123037 cites W2019031643 @default.
• W2005123037 cites W2026288870 @default.
• W2005123037 cites W2036862498 @default.
• W2005123037 cites W2040396943 @default.
• W2005123037 cites W2041200806 @default.
• W2005123037 cites W2076214405 @default.
• W2005123037 cites W2079336499 @default.
• W2005123037 cites W2083138429 @default.
• W2005123037 cites W2098174216 @default.
• W2005123037 cites W2103158448 @default.
• W2005123037 cites W2132076485 @default.
• W2005123037 cites W2136782994 @default.
• W2005123037 cites W2151486690 @default.
• W2005123037 cites W2167829945 @default.
• W2005123037 cites W2314938037 @default.
• W2005123037 cites W2322266245 @default.
• W2005123037 doi "https://doi.org/10.1016/j.cancergencyto.2008.12.013" @default.
• W2005123037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19389502" @default.
• W2005123037 hasPublicationYear "2009" @default.
• W2005123037 type Work @default.
• W2005123037 sameAs 2005123037 @default.
• W2005123037 citedByCount "10" @default.
• W2005123037 countsByYear W20051230372012 @default.
• W2005123037 countsByYear W20051230372013 @default.
• W2005123037 countsByYear W20051230372016 @default.
• W2005123037 countsByYear W20051230372020 @default.
• W2005123037 crossrefType "journal-article" @default.
• W2005123037 hasAuthorship W2005123037A5000865985 @default.
• W2005123037 hasAuthorship W2005123037A5010946531 @default.
• W2005123037 hasAuthorship W2005123037A5017857983 @default.
• W2005123037 hasAuthorship W2005123037A5031444581 @default.
• W2005123037 hasAuthorship W2005123037A5037131671 @default.
• W2005123037 hasAuthorship W2005123037A5045455980 @default.
• W2005123037 hasAuthorship W2005123037A5046844133 @default.
• W2005123037 hasAuthorship W2005123037A5058444378 @default.
• W2005123037 hasAuthorship W2005123037A5060416371 @default.
• W2005123037 hasAuthorship W2005123037A5060675816 @default.
• W2005123037 hasAuthorship W2005123037A5088310937 @default.
• W2005123037 hasConcept C104317684 @default.
• W2005123037 hasConcept C126322002 @default.
• W2005123037 hasConcept C138626823 @default.
• W2005123037 hasConcept C174475383 @default.
• W2005123037 hasConcept C2776229224 @default.
• W2005123037 hasConcept C2777583451 @default.
• W2005123037 hasConcept C2778729363 @default.
• W2005123037 hasConcept C2778904597 @default.
• W2005123037 hasConcept C2780189214 @default.
• W2005123037 hasConcept C2780365373 @default.
• W2005123037 hasConcept C3019892230 @default.
• W2005123037 hasConcept C30481170 @default.
• W2005123037 hasConcept C53226629 @default.
• W2005123037 hasConcept C54355233 @default.
• W2005123037 hasConcept C71924100 @default.
• W2005123037 hasConcept C86803240 @default.
• W2005123037 hasConcept C90924648 @default.
• W2005123037 hasConceptScore W2005123037C104317684 @default.
• W2005123037 hasConceptScore W2005123037C126322002 @default.
• W2005123037 hasConceptScore W2005123037C138626823 @default.
• W2005123037 hasConceptScore W2005123037C174475383 @default.
• W2005123037 hasConceptScore W2005123037C2776229224 @default.
• W2005123037 hasConceptScore W2005123037C2777583451 @default.
• W2005123037 hasConceptScore W2005123037C2778729363 @default.
• W2005123037 hasConceptScore W2005123037C2778904597 @default.
• W2005123037 hasConceptScore W2005123037C2780189214 @default.
• W2005123037 hasConceptScore W2005123037C2780365373 @default.
• W2005123037 hasConceptScore W2005123037C3019892230 @default.
• W2005123037 hasConceptScore W2005123037C30481170 @default.
• W2005123037 hasConceptScore W2005123037C53226629 @default.
• W2005123037 hasConceptScore W2005123037C54355233 @default.
• W2005123037 hasConceptScore W2005123037C71924100 @default.
• W2005123037 hasConceptScore W2005123037C86803240 @default.
• W2005123037 hasConceptScore W2005123037C90924648 @default.
• W2005123037 hasIssue "1" @default.

• next